Recombinant human CAMK1G protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CAMK1G also known as Calcium/Calmodulin-dependent protein kinase 1G is a member of the CAMK1 family of serine/threonine protein kinases. It has a mass of approximately 44 kDa. This kinase is involved in phosphorylating and activating various proteins dependent on calcium and calmodulin. CAMK1G is expressed most significantly in the brain and is also found in other tissues such as the liver and kidneys.

Biological function summary

This kinase regulates neuronal activities and cognitive processes. CAMK1G plays an important role in the modulation of synaptic plasticity and neurotransmitter release. It forms part of a larger signaling complex with other proteins that respond to calcium levels influencing various calcium-mediated cellular processes. This kinase supports the functioning of neurons affecting learning and memory.

Pathways

CAMK1G integrates within the calcium signaling and MAPK pathways. It interacts with other proteins such as CAMK1D influencing synaptic transmission and plasticity. The connections to these pathways help regulate processes like gene transcription and cellular response to growth factors essential for neuronal health and adaptation.

CAMK1G is linked to neurological conditions such as Alzheimer's disease and psychiatric disorders like schizophrenia. The dysregulation of calcium signaling pathways involving CAMK1G and its related proteins such as CAMK1A and CAMK1D could contribute to neurodegenerative disease progression affecting cognitive function and memory retention. This relationship highlights the importance of CAMK1G in maintaining neuronal integrity and mental health.