Recombinant human CamKII gamma protein (Active) is a Human Full Length protein, in the 1 to 558 aa range, expressed in Baculovirus infected Sf9, with >75% purity and suitable for SDS-PAGE, FuncS.
M A T T A T C T R F T D D Y Q L F E E L G K G A F S V V R R C V K K T S T Q E Y A A K I I N T K K L S A R D H Q K L E R E A R I C R L L K H P N I V R L H D S I S E E G F H Y L V F D L V T G G E L F E D I V A R E Y Y S E A D A S H C I H Q I L E S V N H I H Q H D I V H R D L K P E N L L L A S K C K G A A V K L A D F G L A I E V Q G E Q Q A W F G F A G T P G Y L S P E V L R K D P Y G K P V D I W A C G V I L Y I L L V G Y P P F W D E D Q H K L Y Q Q I K A G A Y D F P S P E W D T V T P E A K N L I N Q M L T I N P A K R I T A D Q A L K H P W V C Q R S T V A S M M H R Q E T V E C L R K F N A R R K L K G A I L T T M L V S R N F S A A K S L L N K K S D G G V K K R K S S S S V H L M P Q S N N K N S L V S P A Q E P A P L Q T A M E P Q T T V V H N A T D G I K G S T E S C N T T T E D E D L K G R V P E G R S S R D R T A P S A G M Q P Q P S L C S S A M R K Q E I I K I T E Q L I E A I N N G D F E A Y T K I C D P G L T S F E P E A L G N L V E G M D F H K F Y F E N L L S K N S K P I H T T I L N P H V H V I G E D A A C I A Y I R L T Q Y I D G Q G R P R T S Q S E E T R V W H R R D G K W L N V H Y H C S G A P A A P L Q
Application | Reactivity | Dilution info | Notes |
---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application FuncS | Reactivity Reacts | Dilution info - | Notes - |
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin (PubMed:16690701). In the central nervous system, it is involved in the regulation of neurite formation and arborization (PubMed:30184290). It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity).
CAMK, CAMK-II, CAMKG, CAMK2G, Calcium/calmodulin-dependent protein kinase type II subunit gamma, CaM kinase II subunit gamma, CaMK-II subunit gamma
Recombinant human CamKII gamma protein (Active) is a Human Full Length protein, in the 1 to 558 aa range, expressed in Baculovirus infected Sf9, with >75% purity and suitable for SDS-PAGE, FuncS.
pH: 7.5
Constituents: 25% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.79% Tris HCl, 0.31% Glutathione, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF
Affinity purified.
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin (PubMed:16690701). In the central nervous system, it is involved in the regulation of neurite formation and arborization (PubMed:30184290). It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity).
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
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The specific activity of ab268378 was 260 nmol/min/mg in a kinase assay using autocamtide 2 synthetic peptide (KKALRR-QETVDAL-amide) as substrate.
SDS-PAGE analysis of ab268378.
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