Skip to main content

Recombinant human CamKII gamma protein (Active) is a Human Full Length protein, in the 1 to 558 aa range, expressed in Baculovirus infected Sf9, with >75% purity and suitable for SDS-PAGE, FuncS.

Be the first to review this product! Submit a review

Images

Functional Studies - Recombinant human CamKII gamma protein (Active) (AB268378), expandable thumbnail
  • SDS-PAGE - Recombinant human CamKII gamma protein (Active) (AB268378), expandable thumbnail

Key facts

Purity
>75% SDS-PAGE
Expression system
Baculovirus infected Sf9 cells
Tags
GST tag N-Terminus
Applications
SDS-PAGE, FuncS
Biologically active
Yes

Amino acid sequence

M A T T A T C T R F T D D Y Q L F E E L G K G A F S V V R R C V K K T S T Q E Y A A K I I N T K K L S A R D H Q K L E R E A R I C R L L K H P N I V R L H D S I S E E G F H Y L V F D L V T G G E L F E D I V A R E Y Y S E A D A S H C I H Q I L E S V N H I H Q H D I V H R D L K P E N L L L A S K C K G A A V K L A D F G L A I E V Q G E Q Q A W F G F A G T P G Y L S P E V L R K D P Y G K P V D I W A C G V I L Y I L L V G Y P P F W D E D Q H K L Y Q Q I K A G A Y D F P S P E W D T V T P E A K N L I N Q M L T I N P A K R I T A D Q A L K H P W V C Q R S T V A S M M H R Q E T V E C L R K F N A R R K L K G A I L T T M L V S R N F S A A K S L L N K K S D G G V K K R K S S S S V H L M P Q S N N K N S L V S P A Q E P A P L Q T A M E P Q T T V V H N A T D G I K G S T E S C N T T T E D E D L K G R V P E G R S S R D R T A P S A G M Q P Q P S L C S S A M R K Q E I I K I T E Q L I E A I N N G D F E A Y T K I C D P G L T S F E P E A L G N L V E G M D F H K F Y F E N L L S K N S K P I H T T I L N P H V H V I G E D A A C I A Y I R L T Q Y I D G Q G R P R T S Q S E E T R V W H R R D G K W L N V H Y H C S G A P A A P L Q

Reactivity data

Application
SDS-PAGE
Reactivity
Reacts
Dilution info
-
Notes

-

Application
FuncS
Reactivity
Reacts
Dilution info
-
Notes

-

Target data

Function

Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin (PubMed:16690701). In the central nervous system, it is involved in the regulation of neurite formation and arborization (PubMed:30184290). It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity).

Alternative names

Recommended products

Recombinant human CamKII gamma protein (Active) is a Human Full Length protein, in the 1 to 558 aa range, expressed in Baculovirus infected Sf9, with >75% purity and suitable for SDS-PAGE, FuncS.

Key facts

Purity
>75% SDS-PAGE
Expression system
Baculovirus infected Sf9 cells
Applications
SDS-PAGE, FuncS
Biological activity
The specific activity of ab268378 was 260 nmol/min/mg in a kinase assay using autocamtide 2 synthetic peptide (KKALRR-QETVDAL-amide) as substrate.
Accession
Q13555-1
Animal free
No
Species
Human
Concentration
Loading...
Storage buffer

pH: 7.5
Constituents: 25% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.79% Tris HCl, 0.31% Glutathione, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF

Sequence info

Amino acid sequence

M A T T A T C T R F T D D Y Q L F E E L G K G A F S V V R R C V K K T S T Q E Y A A K I I N T K K L S A R D H Q K L E R E A R I C R L L K H P N I V R L H D S I S E E G F H Y L V F D L V T G G E L F E D I V A R E Y Y S E A D A S H C I H Q I L E S V N H I H Q H D I V H R D L K P E N L L L A S K C K G A A V K L A D F G L A I E V Q G E Q Q A W F G F A G T P G Y L S P E V L R K D P Y G K P V D I W A C G V I L Y I L L V G Y P P F W D E D Q H K L Y Q Q I K A G A Y D F P S P E W D T V T P E A K N L I N Q M L T I N P A K R I T A D Q A L K H P W V C Q R S T V A S M M H R Q E T V E C L R K F N A R R K L K G A I L T T M L V S R N F S A A K S L L N K K S D G G V K K R K S S S S V H L M P Q S N N K N S L V S P A Q E P A P L Q T A M E P Q T T V V H N A T D G I K G S T E S C N T T T E D E D L K G R V P E G R S S R D R T A P S A G M Q P Q P S L C S S A M R K Q E I I K I T E Q L I E A I N N G D F E A Y T K I C D P G L T S F E P E A L G N L V E G M D F H K F Y F E N L L S K N S K P I H T T I L N P H V H V I G E D A A C I A Y I R L T Q Y I D G Q G R P R T S Q S E E T R V W H R R D G K W L N V H Y H C S G A P A A P L Q
Accession
Q13555
Protein length
Full Length
Amino acids
1 to 558
Nature
Recombinant
Tags
GST tag N-Terminus

Specifications

Form
Liquid
Additional notes

Affinity purified.

General info

Function

Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin (PubMed:16690701). In the central nervous system, it is involved in the regulation of neurite formation and arborization (PubMed:30184290). It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity).

Sequence similarities

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

Post-translational modifications

Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state.

Storage

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

This product is an active protein and may elicit a biological response in vivo, handle with caution.

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

2 product images

  • Functional Studies - Recombinant human CamKII gamma protein (Active) (ab268378), expandable thumbnail

    Functional Studies - Recombinant human CamKII gamma protein (Active) (ab268378)

    The specific activity of ab268378 was 260 nmol/min/mg in a kinase assay using autocamtide 2 synthetic peptide (KKALRR-QETVDAL-amide) as substrate.

  • SDS-PAGE - Recombinant human CamKII gamma protein (Active) (ab268378), expandable thumbnail

    SDS-PAGE - Recombinant human CamKII gamma protein (Active) (ab268378)

    SDS-PAGE analysis of ab268378.

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com