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AB167835

Recombinant Human CAMLG/CAML protein (His tag N-Terminus)

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Recombinant Human CAMLG/CAML protein (His tag N-Terminus) is a Human Fragment protein, in the 1 to 189 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

CAML, GET2, CAMLG, Guided entry of tail-anchored proteins factor CAMLG, Calcium signal-modulating cyclophilin ligand

1 Images
SDS-PAGE - Recombinant Human CAMLG/CAML protein (His tag N-Terminus) (AB167835)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human CAMLG/CAML protein (His tag N-Terminus) (AB167835)

SDS-PAGE analysis of ab167835 (3 µg) under reducing condition and visualized by Coomassie blue stain.

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

P49069

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as CAMLG
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMESMAVATDGGERPGVPAGSGLSASQRRAELRRRKLLMNSEQRINRIMGFHRPGSGAEEESQTKSKQQDSDKLNSLSVPSVSKRVVLGDSVSTGTTDQQGGVAEVKGTQLGDKLDSFIKPPECSSDVNLELRQRNRGDLTADSVQRGSRHGLEQYLSRFEEAMKLRKQLISEKPSQEDGNTTEEFDSFR","proteinLength":"Fragment","predictedMolecularWeight":"23.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":189,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P49069","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CAMLG also known as CAML (calcium modulating ligand) is a protein with a molecular mass of approximately 37 kDa. CAMLG has an essential role in cellular calcium signaling processes. It is predominantly expressed in the endoplasmic reticulum membrane in various cell types. CAMLG's function involves mediating calcium influx and maintenance which affects multiple cellular operations. The protein interacts with membrane-bound elements facilitating its role in signaling and cellular homeostasis.
Biological function summary

CAMLG contributes to proper cellular signaling and function by managing calcium flux. It is part of larger protein complexes that regulate calcium-dependent cellular activities. CAMLG assists in the modulation of intracellular calcium levels that influence processes like cell proliferation differentiation and apoptosis. As part of its complex interactions CAMLG collaborates with other proteins involved in calcium signal transduction.

Pathways

Cellular calcium homeostasis mechanisms feature CAMLG as a critical component. This protein functions within pathways such as the NFAT (nuclear factor of activated T-cells) signaling and IP3 (inositol 145-trisphosphate) pathway. In these systems CAMLG interacts with other proteins like IP3 receptor affecting the release and regulation of calcium ions which impact gene transcription and immune response.

Dysfunction in CAMLG activity relates to immune system irregularities and cancer. Disruption in calcium signaling pathways implicates CAMLG in conditions like autoimmune disorders affecting immune cell regulation. Abnormal expression or mutations in CAMLG may also contribute to cancerous cell proliferation when linked to proteins such as NFAT emphasizing its involvement in oncogenic pathways.
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Specifications

Form

Liquid

Additional notes

ab167835 was purified using conventional chromatography techniques.

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General info

Function

Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (PubMed : 23041287, PubMed : 24392163, PubMed : 27226539). Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol (PubMed : 23041287, PubMed : 24392163, PubMed : 27226539). Required for the stability of GET1 (PubMed : 32187542). Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium (PubMed : 7522304). Essential for the survival of peripheral follicular B cells (By similarity).

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Product protocols

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Target data

Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (PubMed : 23041287, PubMed : 24392163, PubMed : 27226539). Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol (PubMed : 23041287, PubMed : 24392163, PubMed : 27226539). Required for the stability of GET1 (PubMed : 32187542). Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium (PubMed : 7522304). Essential for the survival of peripheral follicular B cells (By similarity).
See full target information CAMLG
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