Recombinant Human CAP1 protein is a Human Full Length protein, in the 1 to 475 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Images
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
Amino acid sequence
M A D M Q N L V E R L E R A V G R L E A V S H T S D M H R G Y A D S P S K A G A A P Y V Q A F D S L L A G P V A E Y L K I S K E I G G D V Q K H A E M V H T G L K L E R A L L V T A S Q C Q Q P A E N K L S D L L A P I S E Q I K E V I T F R E K N R G S K L F N H L S A V S E S I Q A L G W V A M A P K P G P Y V K E M N D A A M F Y T N R V L K E Y K D V D K K H V D W V K A Y L S I W T E L Q A Y I K E F H T T G L A W S K T G P V A K E L S G L P S G P S A G S G P P P P P P G P P P P P V S T S S G S D E S A S R S A L F A Q I N Q G E S I T H A L K H V S D D M K T H K N P A L K A Q S G P V R S G P K P F S A P K P Q T S P S P K R A T K K E P A V L E L E G K K W R V E N Q E N V S N L V I E D T E L K Q V A Y I Y K C V N T T L Q I K G K I N S I T V D N C K K L G L V F D D V V G I V E I I N S K D V K V Q V M G K V P T I S I N K T D G C H A Y L S K N S L D C E I V S A K S S E M N V L I P T E G G D F N E F P V P E Q F K T L W N G Q K L V T T V T E I A G
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.
Alternative names
CAP, CAP1, Adenylyl cyclase-associated protein 1, CAP 1
Recommended products
Recombinant Human CAP1 protein is a Human Full Length protein, in the 1 to 475 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
- Accession
- Q01518-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- M A D M Q N L V E R L E R A V G R L E A V S H T S D M H R G Y A D S P S K A G A A P Y V Q A F D S L L A G P V A E Y L K I S K E I G G D V Q K H A E M V H T G L K L E R A L L V T A S Q C Q Q P A E N K L S D L L A P I S E Q I K E V I T F R E K N R G S K L F N H L S A V S E S I Q A L G W V A M A P K P G P Y V K E M N D A A M F Y T N R V L K E Y K D V D K K H V D W V K A Y L S I W T E L Q A Y I K E F H T T G L A W S K T G P V A K E L S G L P S G P S A G S G P P P P P P G P P P P P V S T S S G S D E S A S R S A L F A Q I N Q G E S I T H A L K H V S D D M K T H K N P A L K A Q S G P V R S G P K P F S A P K P Q T S P S P K R A T K K E P A V L E L E G K K W R V E N Q E N V S N L V I E D T E L K Q V A Y I Y K C V N T T L Q I K G K I N S I T V D N C K K L G L V F D D V V G I V E I I N S K D V K V Q V M G K V P T I S I N K T D G C H A Y L S K N S L D C E I V S A K S S E M N V L I P T E G G D F N E F P V P E Q F K T L W N G Q K L V T T V T E I A G
- Accession
- Q01518
- Protein length
- Full Length
- Amino acids
- 1 to 475
- Nature
- Recombinant
- Tags
- GST tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.
- Sequence similarities
Belongs to the CAP family.
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The CAP1 protein also known as Cyclase-associated protein 1 is a dynamic actin-binding protein found in various tissues throughout the body. CAP1 has a mass of approximately 53 kDa. It is predominantly expressed in immune cells and muscle tissue. Mechanically CAP1 interacts with actin filaments promoting their disassembly and turnover therefore facilitating cytoskeletal restructuring critical for cell motility and shape changes.
- Biological function summary
CAP1 plays a significant role in cellular signaling and organization. It does not exist as an isolated entity but instead forms complexes with actin and other cytoskeletal proteins to exert its functions. By promoting actin turnover CAP1 influences processes like intracellular trafficking and cell migration. This protein also contributes to the regulation of signal transduction pathways connected to cell proliferation and differentiation.
- Pathways
CAP1 is involved in the reorganization of the actin cytoskeleton and the Wnt signaling pathway. In actin reorganization CAP1 works closely with cofilin another actin-binding protein to enhance actin dynamics. Through the Wnt pathway CAP1 modulates transcriptional activity and cellular responses to growth signals. These interactions highlight CAP1's integration into important pathways that regulate cell behavior.
- Associated diseases and disorders
CAP1 is relevant in cancer progression and rheumatoid arthritis. In cancer abnormal regulation of CAP1 can lead to enhanced cell migration and invasion which are hallmarks of metastasis. Its interaction with proteins such as cofilin in cytoskeletal rearrangement impacts tumor cell dynamics. In rheumatoid arthritis altered CAP1 activity affects immune cell function and joint degradation. These connections highlight CAP1's importance in pathological conditions where actin dynamics and immune responses play critical roles.
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1 product image
SDS-PAGE - Recombinant Human CAP1 protein (ab161016)
ab161016 on a 12.5% SDS-PAGE stained with Coomassie Blue.
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Product protocols
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