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AB164557

Recombinant Human CAPNS2 protein (GST tag N-Terminus)

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Recombinant Human CAPNS2 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 248 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

Calpain small subunit 2, CSS2, Calcium-dependent protease small subunit 2, CAPNS2

1 Images
SDS-PAGE - Recombinant Human CAPNS2 protein (GST tag N-Terminus) (AB164557)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human CAPNS2 protein (GST tag N-Terminus) (AB164557)

ab164557 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Q96L46

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as Calpain S2.
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Sequence info

[{"sequence":"MFLAKALLEGADRGLGEALGGLFGGGGQRREGGGRNIGGIVGGIVNFISEAAAAQYTPEPPPTQQHFTSVEASESEEVRRFRQQFTQLAGPDMEVGATDLMNILNKVLSKHKDLKTDGFSLDTCRSIVSVMDSDTTGKLGFEEFKYLWNNIKKWQCVYKQYDRDHSGSLGSSQLRGALQAAGFQLNEQLYQMIVRRYANEDGDMDFNNFISCLVRLDAMFRAFKSLDRDRDGLIQVSIKEWLQLTMYS","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":248,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q96L46","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CAPNS2 also known as Calpain Small Subunit 2 or CSS2 is a protein that is part of the calpain family a group of calcium-dependent non-lysosomal cysteine proteases. It has a molecular mass of approximately 29 kDa. CAPNS2 plays a role in intracellular signaling processes by mediating the cleavage of various substrates. It is expressed in numerous tissues with higher levels observed in skeletal muscle and brain reflecting its diverse physiological roles.
Biological function summary

CAPNS2 contributes to the regulation and modulation of cytoskeletal remodeling and cell motility. As a component of the calpain holoenzyme complex it partners with the large catalytic subunits CAPN1 and CAPN2 facilitating the calpain's proteolytic activity. This relationship highlights CAPNS2's role in enabling precise and controlled cellular processes such as cell cycle progression and signal transduction.

Pathways

CAPNS2 integrates into the calcium signaling pathway and is involved in the regulation of the cytoskeleton. In the calcium signaling pathway it interacts with CAPN2 participating in the activation of downstream effectors that convey calcium's pivotal roles in cellular functions. Additionally through its engagement in cytoskeletal reorganization CAPNS2 influences cell shape and migration playing a part alongside proteins like filamin and talin.

CAPNS2's malfunction or deregulation associates with neurodegenerative diseases and muscular dystrophies. In neurodegenerative conditions such as Alzheimer's CAPNS2 interacts with tau protein where dysregulation may contribute to neuronal cell death. Its role in muscular dystrophies links to the impaired function of related proteins like dystrophin underlining the importance of CAPNS2 in maintaining muscle integrity and function.
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Specifications

Form

Liquid

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General info

Function

Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity.

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Product protocols

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Target data

Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity.
See full target information CAPNS2
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