Recombinant Human CARHSP1 protein (His tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CARHSP1 also known as Calcium-regulated Heat Stable Protein 1 is a 15 kDa protein. It plays a significant role in RNA-binding and stabilization influencing RNA metabolism. This protein is expressed in various human tissues including liver heart and muscle which suggests its importance across different biological processes. CARHSP1 has a strong affinity for specific RNA sequences which contributes to its function in post-transcriptional regulation.

Biological function summary

CARHSP1 influences cellular stress responses through its role in RNA stability. It associates with RNA-protein complexes modulating the expression of stress-responsive genes. This protein becomes particularly active under stress conditions like heat shock facilitating survival and adaptation. Its interaction with other elements of the stress granules points to its integrative role in cellular adaptability mechanisms.

Pathways

CARHSP1 participates prominently in post-transcriptional gene regulation pathways. The protein is actively involved in the stress response pathway where it stabilizes target mRNAs during cellular stress conditions. CARHSP1 interacts with proteins such as TIA1 and G3BP key players in the assembly of stress granules further assisting in the stabilization and regulation of specific mRNA transcripts.

Studies suggest that CARHSP1 has implications in certain cancer types and neurodegenerative diseases. Its overexpression or dysregulation may contribute to oncogenic processes in some cancers possibly due to its role in mRNA stabilization of proliferation-related genes. Additionally alterations in CARHSP1 function might relate to neurodegenerative diseases where aberrant stress response pathways are often observed. It connects with proteins like Hsp70 which are also involved in stress and disease response pathways further underlining its potential impact on these conditions.