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AB177662

Recombinant Human Casein Kinase 1 alpha protein (denatured) (His tag N-Terminus)

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Recombinant Human Casein Kinase 1 alpha protein (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 1 to 337 aa range, expressed in Escherichia coli, with >80%, suitable for SDS-PAGE.

View Alternative Names

Casein kinase I isoform alpha, CKI-alpha, CK1, CSNK1A1

1 Images
SDS-PAGE - Recombinant Human Casein Kinase 1 alpha protein (denatured) (His tag N-Terminus) (AB177662)
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Supplier Data

SDS-PAGE - Recombinant Human Casein Kinase 1 alpha protein (denatured) (His tag N-Terminus) (AB177662)

15% SDS-PAGE analysis of ab177662 (3 μg)

Key facts

Purity

>80% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P48729

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

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Complementary Products

Primary Antibodies

AB206652

Anti-Casein Kinase 1 alpha antibody [EPR19824]

RabMAb|Recombinant|KO Validated|Trial Size

Immunoprecipitation - Anti-Casein Kinase 1 alpha antibody [EPR19824] (AB206652)

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Proteins & Peptides

AB103955

Recombinant human Casein Kinase 1 delta/CSNK1D protein

Functional Studies - Recombinant human Casein Kinase 1 delta/CSNK1D protein (AB103955)

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Proteins & Peptides

AB235857

Recombinant Human Androgen Receptor protein (Tagged)

SDS-PAGE - Recombinant Human Androgen Receptor protein (Tagged) (AB235857)

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Proteins & Peptides

AB86846

Recombinant Human Aurora A protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human Aurora A protein (AB86846)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGKQTDKTKSNMKGF","proteinLength":"Full Length","predictedMolecularWeight":"41 kDa","actualMolecularWeight":null,"aminoAcidEnd":337,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P48729","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Specifications

Form

Liquid

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General info

Function

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (PubMed : 11955436, PubMed : 1409656, PubMed : 18305108, PubMed : 23902688). It can phosphorylate a large number of proteins (PubMed : 11955436, PubMed : 1409656, PubMed : 18305108, PubMed : 23902688). Participates in Wnt signaling (PubMed : 11955436). Phosphorylates CTNNB1 at 'Ser-45' (PubMed : 11955436). May phosphorylate PER1 and PER2 (By similarity). May play a role in segregating chromosomes during mitosis (PubMed : 1409656). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed : 23902688). Acts as a positive regulator of mTORC1 and mTORC2 signaling in response to nutrients by mediating phosphorylation of DEPTOR inhibitor (PubMed : 22017875, PubMed : 22017877). Acts as an inhibitor of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity).

Sequence similarities

Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.

Post-translational modifications

Phosphorylated by MTOR in response to mitogenic stimulation, leading to its activation.

Subcellular localisation

Cytoskeleton

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Product protocols

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Target data

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (PubMed : 11955436, PubMed : 1409656, PubMed : 18305108, PubMed : 23902688). It can phosphorylate a large number of proteins (PubMed : 11955436, PubMed : 1409656, PubMed : 18305108, PubMed : 23902688). Participates in Wnt signaling (PubMed : 11955436). Phosphorylates CTNNB1 at 'Ser-45' (PubMed : 11955436). May phosphorylate PER1 and PER2 (By similarity). May play a role in segregating chromosomes during mitosis (PubMed : 1409656). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed : 23902688). Acts as a positive regulator of mTORC1 and mTORC2 signaling in response to nutrients by mediating phosphorylation of DEPTOR inhibitor (PubMed : 22017875, PubMed : 22017877). Acts as an inhibitor of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity).
See full target information CSNK1A1
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