Recombinant Human CASP protein (denatured) (His tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

CASP proteins serve as key mediators in apoptosis and inflammation. They are members of the caspase cascade an essential cell signaling pathway. These proteins can be activated in response to specific cellular stress signals often forming complexes like the apoptosome with other molecules such as cytochrome c and APAF1. The formation of these complexes allows CASP proteins to regulate the cell fate and maintain cellular homeostasis limiting excessive inflammation and tissue damage.

Pathways

CASP proteins play roles in both the intrinsic and extrinsic apoptotic pathways. In the extrinsic pathway signals are received through death receptors leading to the activation of initiator caspases like CASP8. Subsequent cleavage and activation of effector caspases such as CASP3 and CASP7 occur. In the intrinsic pathway CASP9 becomes activated through mitochondrial signals and then facilitates activation of downstream effector caspases. These pathways ensure that CASP proteins interconnect with various pro-apoptotic and anti-apoptotic proteins to effectuate cell death.