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AB158237

Recombinant Human Cathepsin O protein

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(1 Publication)

Recombinant Human Cathepsin O protein is a Human Full Length protein, in the 24 to 321 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

CTSO1, CTSO, Cathepsin O

1 Images
SDS-PAGE - Recombinant Human Cathepsin O protein (AB158237)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Cathepsin O protein (AB158237)

ab158237 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

P43234

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

Sequence info

[{"sequence":"DSRAPFTPTWPRSREREAAAFRESLNRHRYLNSLFPSENSTAFYGINQFSYLFPEEFKAIYLRSKPSKFPRYSAEVHMSIPNVSLPLRFDWRDKQVVTQVRNQQMCGGCWAFSVVGAVESAYAIKGKPLEDLSVQQVIDCSYNNYGCNGGSTLNALNWLNKMQVKLVKDSEYPFKAQNGLCHYFSGSHSGFSIKGYSAYDFSDQEDEMAKALLTFGPLVVIVDAVSWQDYLGGIIQHHCSSGEANHAVLITGFDKTGSTPYWIVRNSWGSSWGVDGYAHVKMGSNVCGIADSVSSIFV","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":321,"aminoAcidStart":24,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"P43234","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]

Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Cathepsin O is a lysosomal cysteine protease from the cathepsin family also known as CTSO. This enzyme has a molecular mass of approximately 36 kDa and plays a role in protein catabolism. It expresses strongly in tissues such as the placenta and thymus. Unlike some other cathepsins Cathepsin O expression is not limited to the lysosomal compartments. It can localize to the cytoplasm under certain conditions which might influence its activity range in breaking down substrates.
Biological function summary

Cathepsin O participates in protein degradation and turnover processes. It function as a protease that breaks peptide bonds aiding in the recycling of cellular components. Though not part of a well-defined complex it cooperates with other proteases to maintain the balance of intracellular proteins. Its activity has implications for cellular homeostasis and likely immune responses due to its expression in immune-related tissues like the thymus.

Pathways

Cathepsin O contributes to intracellular protein degradation pathways particularly involving proteolysis. It has connections with lysosomal degradation pathways and the ubiquitin-proteasome system. Cathepsin L and Cathepsin B operate similarly within these pathways suggesting that Cathepsin O may work in concert or compensate for deficiencies in these enzymes. This ties Cathepsin O to critical cellular processes maintaining protein quality control and regulating cell structure components.

Overexpression or misregulation of Cathepsin O associates with cancer and neurodegenerative diseases. In cancer for example its proteolytic activity might facilitate tumor cell invasion by degrading extracellular matrix components. It relates to Alzheimer's disease due to protease activity disrupting normal turnover of neuronal components potentially linking with proteins like amyloid precursor protein. Such connections highlight its likely role in pathological processes and how modifiers of Cathepsin O activity might offer therapeutic potential.

Specifications

Form

Liquid

General info

Function

Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover.

Sequence similarities

Belongs to the peptidase C1 family.

Subcellular localisation

Lysosome

Product protocols

Target data

Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover.
See full target information CTSO

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Alzheimer's & dementia : the journal of the Alzheimer's Association 21:e70320 PubMed40469052

2025

Tau phosphorylation at Alzheimer's disease biomarker sites impairs its cleavage by lysosomal proteases.

Applications

Unspecified application

Species

Unspecified reactive species

Courtney Lane-Donovan,Andrew W Smith,Rowan Saloner,Bruce L Miller,Kaitlin B Casaletto,Aimee W Kao
View all publications

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