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AB198089

Recombinant human Cathepsin V protein

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Recombinant human Cathepsin V protein is a Human Full Length protein, in the 18 to 334 aa range, expressed in Mammalian, with >90%, suitable for SDS-PAGE, FuncS.

View Alternative Names

CATL2, CTSL2, CTSU, UNQ268/PRO305, CTSV, Cathepsin L2, Cathepsin U, Cathepsin V

2 Images
Functional Studies - Recombinant human Cathepsin V protein (AB198089)
  • FuncS

Supplier Data

Functional Studies - Recombinant human Cathepsin V protein (AB198089)

Activity assay using ab198089.

SDS-PAGE - Recombinant human Cathepsin V protein (AB198089)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant human Cathepsin V protein (AB198089)

10% SDS-PAGE analysis of 3 μg of ab198089 with Coomassie staining.

Key facts

Purity

>90% SDS-PAGE

Expression system

Mammalian

Tags

His tag C-Terminus

Applications

SDS-PAGE, FuncS

applications

Biologically active

Yes

Biological activity

Specific Activity: ≥ 436 pmol/min/μg.

Assay Conditions: 25 mM sodium acetate pH 5.5, 0.1 M NaCl, 5 mM DTT, 25 μM substrate (Z-Leu-Arg-AMC), 5 min, room temperature.

Accession

O60911

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 5 Preservative: 1.53% Imidazole Constituents: 10% Glycerol (glycerin, glycerine), 0.72% Sodium chloride, 0.71% Tris HCl, 0.05% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.02% Potassium chloride

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

ab198089 is expressed in FreeStyle 293-F cells.
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Sequence info

[{"sequence":"VPKFDQNLDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIELHNGEYSQGKHGFTMAMNAFGDMTNEEFRQMMGCFRNQKFRKGKVFREPLFLDLPKSVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV","proteinLength":"Full Length","predictedMolecularWeight":"37 kDa","actualMolecularWeight":null,"aminoAcidEnd":334,"aminoAcidStart":18,"nature":"Recombinant","expressionSystem":"Mammalian","accessionNumber":"O60911","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Storage information
Avoid freeze / thaw cycle
True
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Cathepsin V also known as cathepsin L2 is a cysteine protease enzyme involved in protein degradation. This enzyme has a molecular mass of approximately 37 kDa. Cathepsin V predominantly resides in lysosomes cellular organelles known for breaking down waste materials. It is highly expressed in thymus cornea and testis suggesting its significant role in tissues that require extensive protein turnover.
Biological function summary

Cathepsin V plays essential roles in the degradation of intracellular proteins by cleaving peptide bonds. Although not part of a complex its activity helps regulate immune responses and processing of antigens keeping cellular functions normal. Cathepsin V shows high proteolytic activity which is suited for tissues where high protein breakdown and recycling are necessary.

Pathways

Cathepsin V participates in pathways linked to protein catabolism and immune system regulation. It takes part in the antigen processing and presentation pathway contributing to immune surveillance. Within these pathways its activity can interact with other proteases like cathepsin S showing functional redundancy or specificity depending on tissue type and conditions.

Cathepsin V is associated with cancer and autoimmune diseases. In some cancers its overexpression may facilitate tumor progression by degrading extracellular matrix components aiding metastasis. This upregulation can involve interaction with proteins such as cathepsin B which also modifies extracellular environments. In autoimmune disorders altered regulation of cathepsin V affects antigen processing possibly leading to abnormal immune responses.
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Specifications

Form

Liquid

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General info

Function

Cysteine protease. May have an important role in corneal physiology.

Sequence similarities

Belongs to the peptidase C1 family.

Subcellular localisation

Lysosome

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Product protocols

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Target data

Cysteine protease. May have an important role in corneal physiology.
See full target information CTSV
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