JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB165120

Recombinant Human CATSPER1 protein (GST tag N-Terminus)

Be the first to review this product! Submit a review

|

(1 Publication)

Recombinant Human CATSPER1 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 780 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

Cation channel sperm-associated protein 1, CatSper1, hCatSper, CATSPER1

1 Images
SDS-PAGE - Recombinant Human CATSPER1 protein (GST tag N-Terminus) (AB165120)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human CATSPER1 protein (GST tag N-Terminus) (AB165120)

ab165120 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Q8NEC5

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

style
left-column

Complementary Products

Proteins & Peptides

AB165455

Recombinant Human ZNF358 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human ZNF358 protein (GST tag N-Terminus) (AB165455)

  • 0
  • 0
Proteins & Peptides

AB165467

Recombinant Human ZBTB46 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human ZBTB46 protein (GST tag N-Terminus) (AB165467)

  • 0
  • 0
Proteins & Peptides

AB164919

Recombinant Human Zinc finger protein 276 (GST tag N-Terminus)

SDS-PAGE - Recombinant Human Zinc finger protein 276 (GST tag N-Terminus) (AB164919)

  • 0
  • 0
Proteins & Peptides

AB165841

Recombinant Human UBR1 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human UBR1 protein (GST tag N-Terminus) (AB165841)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Sequence info

[{"sequence":"MDQNSVPEKAQNEADTNNADRFFRSHSSPPHHRPGHSRALHHYELHHHGVPHQRGESHHPPEFQDFHDQALSSHVHQSHHHSEARNHGRAHGPTGFGLAPSQGAVPSHRSYGEDYHDELQRDGRRHHDGSQYGGFHQQSDSHYHRGSHHGRPQYLGENLSHYSSGVPHHGEASHHGGSYLPHGPNPYSESFHHSEASHLSGLQHDESQHHQVPHRGWPHHHQVHHHGRSRHHEAHQHGKSPHHGETISPHSSVGSYQRGISDYHSEYHQGDHHPSEYHHGDHPHHTQHHYHQTHRHRDYHQHQDHHGAYHSSYLHGDYVQSTSQLSIPHTSRSLIHDAPGPAASRTGVFPYHVAHPRGSAHSMTRSSSTIRSRVTQMSKKVHTQDISTKHSEDWGKEEGQFQKRKTGRLQRTRKKGHSTNLFQWLWEKLTFLIQGFREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEALLKIIALGLSYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSLFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALFRKSDPKRFQNIFTTIFTLFTLLTLDDWSLIYMDSRAQGAWYIIPILIIYIIIQYFIFLNLVITVLVDSFQTALFKGLEKAKQERAARIQEKLLEDSLTELRAAEPKEVASEGTMLKRLIEKKFGTMTEKQQELLFHYLQLVASVEQEQQKFRSQAAVIDEIVDTTFEAGEEDFRN","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":780,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q8NEC5","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
style
left-column

Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CATSPER1 also known as Cation Channel Sperm-Associated Protein Subunit alpha is a protein of approximately 113 kDa. It serves as a calcium channel located in the plasma membrane of sperm cells. Its expression is specific to testis tissue where it plays a role in reproductive biology. The structure of CATSPER1 contains six transmembrane domains that help it function as part of a greater channel complex in sperm cells.
Biological function summary

The CATSPER1 protein is essential for sperm motility and fertility processes. It forms part of the larger CATSPER complex which also includes CATSPER2 CATSPER3 and CATSPER4 as well as other accessory proteins. This channel complex regulates calcium ions' entry into sperm facilitating hyperactivation a critical step for sperm movement through the female reproductive tract and successful fertilization.

Pathways

The CATSPER channel complex participates in the ion transport pathway specifically handling the influx of calcium ions important for sperm activation. It interacts with proteins like the auxiliary CATSPERβ and CATSPERγ which modulate its function. The CATSPER channel also links to the CatSper signaling pathway essential for chemotaxis and sperm navigation during fertilization.

Mutations or defects in the CATSPER1 gene have associations with male infertility manifesting as immotile sperm or impaired hyperactivation. The protein relates to idiopathic infertility cases where CATSPER1 dysfunction occurs in the absence of other evident causes. Additionally its malfunction connects to other CATSPER family proteins such as CATSPER2 contributing to similar reproductive deficiencies.
style
left-column

Specifications

Form

Liquid

style
left-column

General info

Function

Pore-forming subunit of the CatSper complex, a sperm-specific voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte.

Sequence similarities

Belongs to the cation channel sperm-associated (TC 1.A.1.19) family.

style
left-column

Product protocols

style
left-column

Target data

Pore-forming subunit of the CatSper complex, a sperm-specific voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte.
See full target information CATSPER1
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of inflammation research 18:7381-7400 PubMed40535354

2025

Feedback Regulation of sPLA2-COX/5-LOX-Ca2+ in Seminal Plasma and Its Impact on Sperm Quality Parameters.

Applications

Unspecified application

Species

Unspecified reactive species

Yongjie Liu,Liang Dai,Fan Zhang,Yang Liu,Xu Li,Wenzhi Ma
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com