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AB198427

Recombinant Human cbx7 protein (His tag N-Terminus)

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Recombinant Human cbx7 protein (His tag N-Terminus) is a Human Fragment protein, in the 2 to 90 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, FuncS.

View Alternative Names

Chromobox protein homolog 7, CBX7

1 Images
SDS-PAGE - Recombinant Human cbx7 protein (His tag N-Terminus) (AB198427)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human cbx7 protein (His tag N-Terminus) (AB198427)

4-20% SDS-PAGE analysis of ab198427 with Coomassie staining.

Lane 1 : 2 μg ab198427
Lane 2 : Protein Marker

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, FuncS

applications

Biologically active

No

Accession

O95931

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.64% Sodium chloride, 0.63% Tris HCl, 0.04% Sorbitan monolaurate, ethoxylated, 0.02% Potassium chloride

storage-buffer

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Complementary Products

Primary Antibodies

AB21873

Anti-cbx7 antibody

BOND RX™ Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-cbx7 antibody (AB21873)

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Recombinant Human WFDC2 Protein (His tag)

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Proteins & Peptides

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Recombinant human XIAP protein (DDDDK tag N-Terminus)

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Proteins & Peptides

AB217407

Recombinant human Vitronectin/S-Protein (Animal Free)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MHHHHHHELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEKEERDRASGYRKRGPKPKRLLLQRLYSMDLR","proteinLength":"Fragment","predictedMolecularWeight":"11.6 kDa","actualMolecularWeight":null,"aminoAcidEnd":90,"aminoAcidStart":2,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"O95931","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CBX7 also known as Chromobox protein homolog 7 is a member of the Polycomb group proteins. It has a molecular mass of approximately 27 kDa. Mechanically CBX7 functions as a transcriptional repressor that interacts with chromatin to maintain the repression of genes involved in development and cell differentiation. The protein is expressed in various tissues with notable levels in embryonic stem cells and certain adult tissues like bone marrow and the immune system.
Biological function summary

The CBX7 protein participates in the complex known as Polycomb Repressive Complex 1 (PRC1). This complex plays a significant role in the maintenance of cellular identity by regulating gene expression profiles important for stem cell pluripotency and differentiation. CBX7 binds to modified histones leading to chromatin compaction and gene silencing instrumental for preserving cell lineage integrity during development and cellular transformation.

Pathways

CBX7 interacts with several components in the cell cycle regulation and epigenetic modification pathways. Within the cell cycle regulation pathway it closely interacts with other Polycomb group proteins to control gene expression that governs cell proliferation and differentiation. In the context of epigenetic pathways CBX7 influences chromatin remodeling by interacting with proteins like BMI1 and RING1 thereby exerting control over the transcriptional landscape required for developmental and adaptive responses.

CBX7 shows a relationship with cancer and developmental disorders. Aberrant expression or mutation of CBX7 has been associated with several cancers including prostate and gastric cancers often connected with the suppression of tumor suppressor genes and cell cycle regulation. In these diseases CBX7 interacts with proteins like E2F6 and MYC which are important for cellular proliferation and growth. Moreover disruptions in CBX7 expression patterns can lead to improper cell differentiation contributing to developmental abnormalities.
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Specifications

Form

Liquid

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General info

Function

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.
See full target information Chromobox protein homolog 7
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Product promise

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