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AB194049

Recombinant Human CCDC134 protein

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Recombinant Human CCDC134 protein is a Human Full Length protein, in the 23 to 229 aa range, expressed in HEK 293 cells, with >95%, < 0.1 EU/µg endotoxin level, suitable for SDS-PAGE, HPLC.

View Alternative Names

Coiled-coil domain-containing protein 134, CCDC134

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 0.1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE, HPLC

applications

Biologically active

No

Accession

Q9H6E4

Animal free

No

Carrier free

No

Species

Human

Reconstitution

Reconstitute in PBS

Storage buffer

pH: 7.4 Constituents: 99% Phosphate Buffer, 0.87% Sodium chloride

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "HPLC": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"TLRTSLDPSLEIYKKMFEVKRREQLLALKNLAQLNDIHQQYKILDVMLKGLFKVLEDSRTVLTAADVLPDGPFPQDEKLKDAFSHVVENTAFFGDVVLRFPRIVHYYFDHNSNWNLLIRWGISFCNQTGVFNQGPHSPILSLMAQELGISEKDSNFQNPFKIDRTEFIPSTDPFQKALREEEKRRKKEEKRKEIRKGPRISRSQSELVDHHHHHH","proteinLength":"Full Length","predictedMolecularWeight":"25.25 kDa","actualMolecularWeight":null,"aminoAcidEnd":229,"aminoAcidStart":23,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q9H6E4","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
A few weeks
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Reconstitute for long term storage
False
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Specifications

Form

Lyophilized

Additional notes

The purity of ab194049 was determined by SEC-HPLC and reducing SDS-PAGE.

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General info

Function

In extracellular secreted form, promotes proliferation and activation of CD8(+) T cells, suggesting a cytokine-like function (PubMed : 25125657). Enhances cytotoxic anti-tumor activity of CD8(+) T cells (PubMed : 25125657). May inhibit ERK and JNK signaling activity (PubMed : 18087676, PubMed : 23070808). May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling (PubMed : 23070808). Has a critical role in the regulation of osteogenesis and bone development (PubMed : 32181939).. In the nucleus, enhances stability of the PCAF histone acetyltransferase (HAT) complex member TADA2A and thus promotes PCAF-mediated H3K14 and H4K8 HAT activity. May inhibit TADA2A-mediated TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote TADA2A-mediated XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage.

Sequence similarities

Belongs to the CCDC134 family.

Post-translational modifications

O-glycosylated, with additional sialic acid modifications.

Subcellular localisation

Nucleus

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Product protocols

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Target data

In extracellular secreted form, promotes proliferation and activation of CD8(+) T cells, suggesting a cytokine-like function (PubMed : 25125657). Enhances cytotoxic anti-tumor activity of CD8(+) T cells (PubMed : 25125657). May inhibit ERK and JNK signaling activity (PubMed : 18087676, PubMed : 23070808). May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling (PubMed : 23070808). Has a critical role in the regulation of osteogenesis and bone development (PubMed : 32181939).. In the nucleus, enhances stability of the PCAF histone acetyltransferase (HAT) complex member TADA2A and thus promotes PCAF-mediated H3K14 and H4K8 HAT activity. May inhibit TADA2A-mediated TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote TADA2A-mediated XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage.
See full target information Coiled-coil domain-containing protein 134
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Primary Antibodies

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