Recombinant Human CCDC134 protein (His tag) is a Human Full Length protein, in the 1 to 229 aa range, expressed in HEK 293, with >98% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
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Key facts
- Purity
>98% SDS-PAGE
- Endotoxin level
< 1 EU/µg
- Expression system
HEK 293 cells
- Tags
His tag C-Terminus
- Applications
SDS-PAGE
- Biologically active
No
Amino acid sequence
M D L L Q F L A F L F V L L L S G M G A T G T L R T S L D P S L E I Y K K M F E V K R R E Q L L A L K N L A Q L N D I H Q Q Y K I L D V M L K G L F K V L E D S R T V L T A A D V L P D G P F P Q D E K L K D A F S H V V E N T A F F G D V V L R F P R I V H Y Y F D H N S N W N L L I R W G I S F C N Q T G V F N Q G P H S P I L S L M A Q E L G I S E K D S N F Q N P F K I D R T E F I P S T D P F Q K A L R E E E K R R K K E E K R K E I R K G P R I S R S Q S E L
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
In extracellular secreted form, promotes proliferation and activation of CD8(+) T cells, suggesting a cytokine-like function (PubMed:25125657). Enhances cytotoxic anti-tumor activity of CD8(+) T cells (PubMed:25125657). May inhibit ERK and JNK signaling activity (PubMed:18087676, PubMed:23070808). May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling (PubMed:23070808).In the nucleus, enhances stability of the PCAF histone acetyltransferase (HAT) complex member TADA2A and thus promotes PCAF-mediated H3K14 and H4K8 HAT activity. May inhibit TADA2A-mediated TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote TADA2A-mediated XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage.
Alternative names
Coiled-coil domain-containing protein 134, CCDC134
Recommended products
Recombinant Human CCDC134 protein (His tag) is a Human Full Length protein, in the 1 to 229 aa range, expressed in HEK 293, with >98% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
Alternative names
Coiled-coil domain-containing protein 134, CCDC134
Key facts
- Purity
>98% SDS-PAGE
- Endotoxin level
< 1 EU/µg
- Expression system
HEK 293 cells
- Tags
His tag C-Terminus
- Applications
SDS-PAGE
- Biologically active
No
- Accession
- Q9H6E4-1
- Animal free
No
- Species
Human
- Concentration
- Storage buffer
pH: 7.4
Constituents: 100% PBS
Sequence info
Amino acid sequence
M D L L Q F L A F L F V L L L S G M G A T G T L R T S L D P S L E I Y K K M F E V K R R E Q L L A L K N L A Q L N D I H Q Q Y K I L D V M L K G L F K V L E D S R T V L T A A D V L P D G P F P Q D E K L K D A F S H V V E N T A F F G D V V L R F P R I V H Y Y F D H N S N W N L L I R W G I S F C N Q T G V F N Q G P H S P I L S L M A Q E L G I S E K D S N F Q N P F K I D R T E F I P S T D P F Q K A L R E E E K R R K K E E K R K E I R K G P R I S R S Q S E L
- Accession
- Protein length
Full Length
- Predicted molecular weight
25.7 kDa
- Amino acids
1 to 229
- Nature
Recombinant
- Tags
His tag C-Terminus
Specifications
- Form
Lyophilized
General info
- Function
In extracellular secreted form, promotes proliferation and activation of CD8(+) T cells, suggesting a cytokine-like function (PubMed:25125657). Enhances cytotoxic anti-tumor activity of CD8(+) T cells (PubMed:25125657). May inhibit ERK and JNK signaling activity (PubMed:18087676, PubMed:23070808). May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling (PubMed:23070808).
- Sequence similarities
Belongs to the CCDC134 family.
- Post-translational modifications
O-glycosylated, with additional sialic acid modifications.
- Subcellular localisation
Nucleus
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Product promise
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1 product image
SDS-PAGE - Recombinant Human CCDC134 protein (His tag) (ab276504)
SDS-PAGE analysis of ab276504
Downloads
Product protocols
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