Recombinant Human CCDC134 protein (His tag) is a Human Full Length protein, in the 1 to 229 aa range, expressed in HEK 293, with >98% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
Images
Key facts
- Purity
- >98% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M D L L Q F L A F L F V L L L S G M G A T G T L R T S L D P S L E I Y K K M F E V K R R E Q L L A L K N L A Q L N D I H Q Q Y K I L D V M L K G L F K V L E D S R T V L T A A D V L P D G P F P Q D E K L K D A F S H V V E N T A F F G D V V L R F P R I V H Y Y F D H N S N W N L L I R W G I S F C N Q T G V F N Q G P H S P I L S L M A Q E L G I S E K D S N F Q N P F K I D R T E F I P S T D P F Q K A L R E E E K R R K K E E K R K E I R K G P R I S R S Q S E L
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
In extracellular secreted form, promotes proliferation and activation of CD8(+) T cells, suggesting a cytokine-like function (PubMed:25125657). Enhances cytotoxic anti-tumor activity of CD8(+) T cells (PubMed:25125657). May inhibit ERK and JNK signaling activity (PubMed:18087676, PubMed:23070808). May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling (PubMed:23070808). Has a critical role in the regulation of osteogenesis and bone development (PubMed:32181939). In the nucleus, enhances stability of the PCAF histone acetyltransferase (HAT) complex member TADA2A and thus promotes PCAF-mediated H3K14 and H4K8 HAT activity. May inhibit TADA2A-mediated TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote TADA2A-mediated XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage.
Alternative names
Coiled-coil domain-containing protein 134, CCDC134
Recommended products
Recombinant Human CCDC134 protein (His tag) is a Human Full Length protein, in the 1 to 229 aa range, expressed in HEK 293, with >98% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
Key facts
- Purity
- >98% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- Q9H6E4-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 7.4
Constituents: 100% PBS
Sequence info
Amino acid sequence
- M D L L Q F L A F L F V L L L S G M G A T G T L R T S L D P S L E I Y K K M F E V K R R E Q L L A L K N L A Q L N D I H Q Q Y K I L D V M L K G L F K V L E D S R T V L T A A D V L P D G P F P Q D E K L K D A F S H V V E N T A F F G D V V L R F P R I V H Y Y F D H N S N W N L L I R W G I S F C N Q T G V F N Q G P H S P I L S L M A Q E L G I S E K D S N F Q N P F K I D R T E F I P S T D P F Q K A L R E E E K R R K K E E K R K E I R K G P R I S R S Q S E L
- Accession
- Q9H6E4
- Protein length
- Full Length
- Predicted molecular weight
- 25.7 kDa
- Amino acids
- 1 to 229
- Nature
- Recombinant
- Tags
- His tag C-Terminus
Specifications
- Form
- Lyophilized
General info
- Function
In extracellular secreted form, promotes proliferation and activation of CD8(+) T cells, suggesting a cytokine-like function (PubMed:25125657). Enhances cytotoxic anti-tumor activity of CD8(+) T cells (PubMed:25125657). May inhibit ERK and JNK signaling activity (PubMed:18087676, PubMed:23070808). May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling (PubMed:23070808). Has a critical role in the regulation of osteogenesis and bone development (PubMed:32181939).
- Sequence similarities
Belongs to the CCDC134 family.
- Post-translational modifications
O-glycosylated, with additional sialic acid modifications.
- Subcellular localisation
- Nucleus
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Product promise
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
1 product image
SDS-PAGE - Recombinant Human CCDC134 protein (His tag) (ab276504)
SDS-PAGE analysis of ab276504
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com