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AB187617

Recombinant Human CCDC23 protein (His tag N-Terminus)

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Recombinant Human CCDC23 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 66 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

CCDC23, SVBP, Small vasohibin-binding protein, Coiled coil domain-containing protein 23

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SDS-PAGE - Recombinant Human CCDC23 protein (AB187617)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human CCDC23 protein (AB187617)

15% SDS-PAGE analysis of ab187617 (3 μg)

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q8N300

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: PBS, 20% Glycerol (glycerin, glycerine), 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSEFMDPPARKEKTKVKESVSRVEKAKQKSAQQELKQRQRAEIYALNRVMTELEQQQFDEFCKQMQPPGE","proteinLength":"Full Length","predictedMolecularWeight":"10.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":66,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q8N300","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Specifications

Form

Liquid

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General info

Function

Enhances the tyrosine carboxypeptidase activity of VASH1 and VASH2, thereby promoting the removal of the C-terminal tyrosine residue of alpha-tubulin (PubMed : 29146869, PubMed : 31171830, PubMed : 31235910, PubMed : 31235911, PubMed : 31270470, PubMed : 31324789). This activity is critical for spindle function and accurate chromosome segregation during mitosis since microtubule detyronisation regulates mitotic spindle length and postioning (PubMed : 31171830). Also required to enhance the solubility and secretion of VASH1 and VASH2 (PubMed : 20736312, PubMed : 27879017, PubMed : 30607023). Plays a role in axon and excitatory synapse formation (PubMed : 31235911).

Sequence similarities

Belongs to the SVBP family.

Subcellular localisation

Cytoskeleton

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Product protocols

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Target data

Enhances the tyrosine carboxypeptidase activity of VASH1 and VASH2, thereby promoting the removal of the C-terminal tyrosine residue of alpha-tubulin (PubMed : 29146869, PubMed : 31171830, PubMed : 31235910, PubMed : 31235911, PubMed : 31270470, PubMed : 31324789). This activity is critical for spindle function and accurate chromosome segregation during mitosis since microtubule detyronisation regulates mitotic spindle length and postioning (PubMed : 31171830). Also required to enhance the solubility and secretion of VASH1 and VASH2 (PubMed : 20736312, PubMed : 27879017, PubMed : 30607023). Plays a role in axon and excitatory synapse formation (PubMed : 31235911).
See full target information SVBP
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