Recombinant Human CCDC25 protein is a Human Full Length protein, in the 1 to 208 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
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Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M G S M V F Y F T S S S V N S S A Y T I Y M G K D K Y E N E D L I K H G W P E D I W F H V D K L S S A H V Y L R L H K G E N I E D I P K E V L M D C A H L V K A N S I Q G C K M N N V N V V Y T P W S N L K K T A D M D V G Q I G F H R Q K D V K I V T V E K K V N E I L N R L E K T K V E R F P D L A A E K E C R D R E E R N E K K A Q I Q E M K K R E K E E M K K K R E M D E L R S Y S S L M K V E N M S S N Q D G N D S D E F M
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Transmembrane receptor that senses neutrophil extracellular traps (NETs) and triggers the ILK-PARVB pathway to enhance cell motility (PubMed:32528174). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (PubMed:32528174). Formation of NETs is also associated with cancer metastasis, NET-DNA acting as a chemotactic factor to attract cancer cells (PubMed:32528174). Specifically binds NETs on its extracellular region, in particular the 8-OHdG-enriched DNA present in NETs, and recruits ILK, initiating the ILK-PARVB cascade to induce cytoskeleton rearrangement and directional migration of cells (PubMed:32528174). In the context of cancer, promotes cancer metastasis by sensing NETs and promoting migration of tumor cells (PubMed:32528174).
Alternative names
Coiled-coil domain-containing protein 25, CCDC25
Recommended products
Recombinant Human CCDC25 protein is a Human Full Length protein, in the 1 to 208 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
- Accession
- Q86WR0-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 20% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M G S M V F Y F T S S S V N S S A Y T I Y M G K D K Y E N E D L I K H G W P E D I W F H V D K L S S A H V Y L R L H K G E N I E D I P K E V L M D C A H L V K A N S I Q G C K M N N V N V V Y T P W S N L K K T A D M D V G Q I G F H R Q K D V K I V T V E K K V N E I L N R L E K T K V E R F P D L A A E K E C R D R E E R N E K K A Q I Q E M K K R E K E E M K K K R E M D E L R S Y S S L M K V E N M S S N Q D G N D S D E F M
- Accession
- Q86WR0
- Protein length
- Full Length
- Predicted molecular weight
- 26.9 kDa
- Amino acids
- 1 to 208
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
ab168088 is purified using conventional chromatography techniques.
General info
- Function
Transmembrane receptor that senses neutrophil extracellular traps (NETs) and triggers the ILK-PARVB pathway to enhance cell motility (PubMed:32528174). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (PubMed:32528174). Formation of NETs is also associated with cancer metastasis, NET-DNA acting as a chemotactic factor to attract cancer cells (PubMed:32528174). Specifically binds NETs on its extracellular region, in particular the 8-OHdG-enriched DNA present in NETs, and recruits ILK, initiating the ILK-PARVB cascade to induce cytoskeleton rearrangement and directional migration of cells (PubMed:32528174). In the context of cancer, promotes cancer metastasis by sensing NETs and promoting migration of tumor cells (PubMed:32528174).
- Sequence similarities
Belongs to the CCDC25 family.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Product promise
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Terms & Conditions.
1 product image
SDS-PAGE - Recombinant Human CCDC25 protein (ab168088)
15% SDS-PAGE analysis of ab168088 (3μg).
Downloads
Product protocols
- Visit the general protocols
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