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AB156720

Recombinant Human CCDC90B protein (His tag N-Terminus)

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Recombinant Human CCDC90B protein (His tag N-Terminus) is a Human Fragment protein, in the 43 to 230 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

CUA003, MDS011, MDS025, CCDC90B

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SDS-PAGE - Recombinant Human CCDC90B protein (His tag N-Terminus) (AB156720)
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SDS-PAGE - Recombinant Human CCDC90B protein (His tag N-Terminus) (AB156720)

15% SDS-PAGE analysis of ab156720 (3μg).

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Q9GZT6

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSGYDRRPVDITPLEQRKLTFDTHALVQDLETHGFDKTQAETIVSALTALSNVSLDTIYKEMVTQAQQEITVQQLMAHLDAIRKDMVILEKSEFANLRAENEKMKIELDQVKQQLMHETSRIRADNKLDINLERSRVTDMFTDQEKQLMETTTEFTKKDTQTKSIISETSNKIDAEIASLKTLMESNKLE","proteinLength":"Fragment","predictedMolecularWeight":"24.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":230,"aminoAcidStart":43,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9GZT6","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CCDC90B also known as coiled-coil domain containing 90B is a protein with a molecular mass of approximately 42 kDa. It is primarily expressed in human tissues such as the brain heart and skeletal muscle. Mechanically CCDC90B interacts with other proteins through its coiled-coil domain which enables protein-protein interactions. It modulates various cellular processes through these interactions although specific functions may vary depending on cell type.
Biological function summary

CCDC90B plays a role in mitochondrial function being part of the mitochondrial inner membrane machinery. It contributes to the assembly and stability of respiratory chain complexes which are essential for cellular energy production. CCDC90B through its interactions can affect mitochondrial dynamics such as fusion and fission which are important for maintaining proper mitochondrial function.

Pathways

CCDC90B activity affects mitochondrial respiratory pathways and the mitophagy pathway. Within the respiratory chain pathway CCDC90B has a connection with elements like the cytochrome c oxidase complex playing a role in ATP synthesis. Its involvement in mitophagy the process responsible for the degradation of damaged mitochondria links CCDC90B to proteins such as PARKIN and PINK1 which are critical for mitochondrial quality control.

CCDC90B has been implicated in mitochondrial disorders which are characterized by defective energy production. Mutations or alterations in CCDC90B may contribute to conditions like Leigh syndrome a severe neurological disorder. Furthermore CCDC90B's functional association with proteins like PINK1 and PARKIN connects it to Parkinson's disease where mitochondrial dysfunction is an important pathological feature.
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Specifications

Form

Liquid

Additional notes

ab1567210 is purified using conventional chromatography techniques.

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General info

Sequence similarities

Belongs to the CCDC90 family.

Subcellular localisation

Mitochondrion membrane

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Product protocols

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Target data

See full target information CCDC90B
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