Recombinant Human CCK4 protein (His tag) is a Human Fragment protein, in the 31 to 704 aa range, expressed in Yeast, with >90% purity and suitable for SDS-PAGE, MS.
>90% SDS-PAGE
Yeast
His tag N-Terminus
SDS-PAGE, MS
No
A I V F I K Q P S S Q D A L Q G R R A L L R C E V E A P G P V H V Y W L L D G A P V Q D T E R R F A Q G S S L S F A A V D R L Q D S G T F Q C V A R D D V T G E E A R S A N A S F N I K W I E A G P V V L K H P A S E A E I Q P Q T Q V T L R C H I D G H P R P T Y Q W F R D G T P L S D G Q S N H T V S S K E R N L T L R P A G P E H S G L Y S C C A H S A F G Q A C S S Q N F T L S I A D E S F A R V V L A P Q D V V V A R Y E E A M F H C Q F S A Q P P P S L Q W L F E D E T P I T N R S R P P H L R R A T V F A N G S L L L T Q V R P R N A G I Y R C I G Q G Q R G P P I I L E A T L H L A E I E D M P L F E P R V F T A G S E E R V T C L P P K G L P E P S V W W E H A G V R L P T H G R V Y Q K G H E L V L A N I A E S D A G V Y T C H A A N L A G Q R R Q D V N I T V A T V P S W L K K P Q D S Q L E E G K P G Y L D C L T Q A T P K P T V V W Y R N Q M L I S E D S R F E V F K N G T L R I N S V E V Y D G T W Y R C M S S T P A G S I E A Q A R V Q V L E K L K F T P P P Q P Q Q C M E F D K E A T V P C S A T G R E K P T I K W E R A D G S S L P E W V T D N A G T L H F A R V T R D D A G N Y T C I A S N G P Q G Q I R A H V Q L T V A V F I T F K V E P E R T T V Y Q G H T A L L Q C E A Q G D P K P L I Q W K G K D R I L D P T K L G P R M H I F Q N G S L V I H D V A P E D S G R Y T C I A G N S C N I K H T E A P L Y V V D K P V P E E S E G P G S P P P Y K M I Q T
Application | Reactivity | Dilution info | Notes |
---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.
CCK4, PTK7, Inactive tyrosine-protein kinase 7, Colon carcinoma kinase 4, Protein-tyrosine kinase 7, Pseudo tyrosine kinase receptor 7, Tyrosine-protein kinase-like 7, CCK-4
Recombinant Human CCK4 protein (His tag) is a Human Fragment protein, in the 31 to 704 aa range, expressed in Yeast, with >90% purity and suitable for SDS-PAGE, MS.
>90% SDS-PAGE
Yeast
His tag N-Terminus
SDS-PAGE, MS
No
No
Human
pH: 7.2 - 7.4
Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)
A I V F I K Q P S S Q D A L Q G R R A L L R C E V E A P G P V H V Y W L L D G A P V Q D T E R R F A Q G S S L S F A A V D R L Q D S G T F Q C V A R D D V T G E E A R S A N A S F N I K W I E A G P V V L K H P A S E A E I Q P Q T Q V T L R C H I D G H P R P T Y Q W F R D G T P L S D G Q S N H T V S S K E R N L T L R P A G P E H S G L Y S C C A H S A F G Q A C S S Q N F T L S I A D E S F A R V V L A P Q D V V V A R Y E E A M F H C Q F S A Q P P P S L Q W L F E D E T P I T N R S R P P H L R R A T V F A N G S L L L T Q V R P R N A G I Y R C I G Q G Q R G P P I I L E A T L H L A E I E D M P L F E P R V F T A G S E E R V T C L P P K G L P E P S V W W E H A G V R L P T H G R V Y Q K G H E L V L A N I A E S D A G V Y T C H A A N L A G Q R R Q D V N I T V A T V P S W L K K P Q D S Q L E E G K P G Y L D C L T Q A T P K P T V V W Y R N Q M L I S E D S R F E V F K N G T L R I N S V E V Y D G T W Y R C M S S T P A G S I E A Q A R V Q V L E K L K F T P P P Q P Q Q C M E F D K E A T V P C S A T G R E K P T I K W E R A D G S S L P E W V T D N A G T L H F A R V T R D D A G N Y T C I A S N G P Q G Q I R A H V Q L T V A V F I T F K V E P E R T T V Y Q G H T A L L Q C E A Q G D P K P L I Q W K G K D R I L D P T K L G P R M H I F Q N G S L V I H D V A P E D S G R Y T C I A G N S C N I K H T E A P L Y V V D K P V P E E S E G P G S P P P Y K M I Q T
Fragment
76.6 kDa
31 to 704
Recombinant
His tag N-Terminus
Liquid
Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
MMP14 cleaves PTK7 between Pro-621 and Leu-622 generating an N-terminal soluble (70 kDa) fragment and a membrane C-terminal (50 kDa) fragment. Proteolysis by MMP14 regulates PTK7 function in non-canonical Wnt signaling pathway.
Blue Ice
-20°C
-20°C
Avoid freeze / thaw cycle
This supplementary information is collated from multiple sources and compiled automatically.
CCK4 also known as PTK7 protein is a receptor tyrosine kinase. The molecular mass of the CCK4 protein is approximately 118 kDa. It is expressed in various tissues including the placenta lung kidney and colon. The presence of CCK4 is particularly noted in developmental tissues and has roles in embryogenesis. Despite its classification as a receptor tyrosine kinase CCK4 lacks catalytic activity indicating its unique functional properties.
CCK4 participates in cellular signaling involved in adhesion and cell migration. It localizes predominantly in the membranes participating in complex cellular environments such as the Wnt signaling complex. This suggests a role in maintaining cellular architecture and signaling pathways that influence developmental processes. Its interactions within these complexes can help maintain balance and functional integrity in developing tissues.
CCK4 engages in vital pathways influencing cell adhesion and movement including the planar cell polarity (PCP) pathway and Wnt signaling pathway. Within these pathways CCK4 interacts with proteins such as Dishevelled and Frizzled establishing its role in guiding cellular and developmental patterns. These interactions regulate important aspects of cell polarity and directional movement during embryonic development.
CCK4 has been implicated in cancer and congenital malformations. In cancers such as colorectal carcinoma altered CCK4 expression correlates with cancer progression possibly through interaction with associated proteins like ROR2. Similarly its function in neural tube development suggests a role in congenital disorders affecting the spine and nervous system. This connection highlights the importance of CCK4 in both cancer biology and developmental disorders.
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(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel analysis of ab241239.
Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of ab241239 could indicate that this peptide derived from Yeast-expressed Homo sapiens (Human) CCK4.
Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of ab241239 could indicate that this peptide derived from Yeast-expressed Homo sapiens (Human) CCK4.
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