Recombinant Human CCL13 Protein (Active)
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Recombinant Human CCL13 Protein (Active) is a Human Full Length protein, in the 24 to 98 aa range, expressed in HEK 293 cells, with >95%, <0.005 EU/µg endotoxin level, suitable for SDS-PAGE, Mass Spec, FuncS, HPLC.
View Alternative Names
MCP4, NCC1, SCYA13, CCL13, C-C motif chemokine 13, CK-beta-10, Monocyte chemoattractant protein 4, Monocyte chemotactic protein 4, NCC-1, Small-inducible cytokine A13, MCP-4
- Biochemical assay
Supplier Data
Biochemical assay - Recombinant Human CCL13 Protein (Active) (AB283922)
Fully biologically active determined by the dose dependent measurement of beta-arrestin recruitment on CCR3 using CHO-K1 overexpressing human CCR3/beta-arrestin/beta-galactosidase complementation system. ED50 is ≤ 181 ng/ml, corresponding to a specific activity of 5.5 x 103 units/mg.
- Mass Spec
Supplier Data
Mass Spectrometry - Recombinant Human CCL13 Protein (Active) (AB283922)
ESI TOF analysis of ab283922.
Predicted MW is 8656.21 Da( +/- 10 Da by ESI TOF). Observed MW is 8655.74 Da.
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human CCL13 Protein (Active) (AB283922)
SDS-PAGE analysis of ab283922.
- HPLC
Supplier Data
HPLC - Recombinant Human CCL13 Protein (Active) (AB283922)
HPLC analysis of ab283922.
Complementary Products
Reactivity data
Sequence info
Properties and storage information
Form
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
MCP4 functions by mediating the recruitment of monocytes eosinophils and T lymphocytes. It is not part of a larger protein complex but rather operates as part of the chemokine signaling family. MCP4 is particularly active in coordinating responses to allergens and pathogens therefore highlighting its importance in the body's defense mechanisms. As a member of the C-C motif chemokine family it shares structural characteristics with other chemokines like CCL11 which participate in similar immune cell trafficking functions.
Pathways
MCP4 is deeply involved in inflammatory and immune pathways specifically the chemokine signaling pathway and the cytokine-cytokine receptor interaction pathway. MCP4 guides immune cells allowing them to respond effectively to cytokine signals ensuring their migration to necessary sites. Through the chemokine signaling pathway it collaborates with related chemokines like CCL5 to enhance immune responses. Its interaction with these pathways highlights its role in both routine immunity and inflammatory responses positioning it as an important player in maintaining immune homeostasis.
General info
Function
Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens.
Sequence similarities
Belongs to the intercrine beta (chemokine CC) family.
Post-translational modifications
One major form (form long), and two minor forms (short chain and medium chain) are produced by differential signal peptide cleavage. The medium chain is about 30-fold less active than the long chain.
Target data
Product promise
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