Recombinant human CCL3 / MIP-1 alpha (Active)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MIP-1 alpha also known as CCL3 or macrophage inflammatory protein 1 alpha is a chemokine with an approximate mass of 10 kDa. It is involved in the immune response by attracting and activating various immune cells such as macrophages and neutrophils. MIP-1 alpha is expressed in a variety of tissues including lymphoid organs inflammatory sites and activated macrophages. This chemokine plays a role in the recruitment of immune cells to the site of infection or injury aiding in the body’s defense mechanisms.

Biological function summary

The regulation of immune cell trafficking involves MIP-1 alpha which acts in both autocrine and paracrine manners. This chemokine functions within a chemokine network facilitating cell signaling pathways necessary for inflammatory responses. MIP-1 alpha does not typically form a complex but operates in close association with other chemokines like MIP-1 beta and RANTES to coordinate immune response.

Pathways

MIP-1 alpha functions prominently in the chemokine signaling pathway and MAPK cascade. It influences the activation of pathways leading to inflammation and leukocyte migration. In interaction MIP-1 alpha is associated with proteins like CCR5 a receptor that mediates its effects on immune cells. These pathways underline its role in orchestrating immune responses required for effective pathogen clearance and inflammation regulation.

MIP-1 alpha associates closely with inflammatory diseases such as rheumatoid arthritis and multiple sclerosis. In rheumatoid arthritis elevated levels of MIP-1 alpha contribute to joint inflammation and pain. Additionally it interacts with proteins like TNF-alpha exacerbating inflammatory processes. MIP-1 alpha’s involvement in autoimmune and inflammatory diseases highlights its potential as a target for therapeutic interventions aimed at modulating immune responses for better disease management.