Recombinant Human CCL4L1 protein (His tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The chemokine CCL4L1 also known as MIP-1β is a protein weighing approximately 8 kDa. It belongs to the CC chemokine family and is encoded on chromosome 17. CCL4L1 is expressed in a variety of tissues including the liver lung and leukocytes. It acts as a ligand for the CCR5 receptor playing a pivotal role in immune surveillance and cell trafficking.

Biological function summary

CCL4L1 orchestrates immune responses by attracting immune cells such as macrophages and monocytes to sites of inflammation or injury. It partners with other chemokines to regulate migration and activation of leukocytes. While not part of a multi-component complex on its own its functional interactions with CCR5 are essential for immune cell signaling pathways.

Pathways

CCL4L1 takes part in the chemokine signaling pathway and the inflammatory response pathway. It communicates with other molecules like CCL3 and CCL5 to coordinate cellular responses that are important for managing inflammation and immune responses. These interactions are essential for the proper functioning of immune surveillance and inflammation resolution.

CCL4L1 has been linked to HIV infection and rheumatoid arthritis. In HIV infection the interaction of CCL4L1 with CCR5 potently influences viral entry into host cells making it an important factor in the disease progression. In rheumatoid arthritis the overexpression of CCL4L1 can exacerbate the recruitment of inflammatory cells contributing to joint inflammation and damage. These connections highlight its potential as a therapeutic target for modulating inflammatory responses and immune-related disorders.