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AB161588

Recombinant Human CCP1 protein (GST tag N-Terminus)

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Recombinant Human CCP1 protein (GST tag N-Terminus) is a Human Fragment protein, in the 1087 to 1186 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

CCP1, KIAA1035, NNA1, AGTPBP1, Cytosolic carboxypeptidase 1, ATP/GTP-binding protein 1, Nervous system nuclear protein induced by axotomy protein 1 homolog, Protein deglutamylase CCP1

1 Images
SDS-PAGE - Recombinant Human CCP1 protein (GST tag N-Terminus) (AB161588)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human CCP1 protein (GST tag N-Terminus) (AB161588)

ab161588 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Q9UPW5

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Complementary Products

Primary Antibodies

AB244512

Anti-CCP1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCP1 antibody (AB244512)

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Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Proteins & Peptides

AB162821

Recombinant Human SLC6A20 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human SLC6A20 protein (GST tag N-Terminus) (AB162821)

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  • 0
Proteins & Peptides

AB161580

Recombinant Human SCC112 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human SCC112 protein (GST tag N-Terminus) (AB161580)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as AGTPBP1.
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Sequence info

[{"sequence":"GAKFCVGLLRLKRLTSPLEYNLPSSLLDFENDLIESSCKVTSPTTYVLDEDEPRFLEEVDYSAESNDELDIELAENVGDYEPSAQEEVLSDSELSRTYLP","proteinLength":"Fragment","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":1186,"aminoAcidStart":1087,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q9UPW5","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CCP1 also known as Cytosolic Carboxypeptidase 1 is an enzymatic protein important in the modulation of microtubule function. This protein is approximately 76 kDa in mass and is mainly expressed in the brain and testes but it can be found in other tissues as well. CCP1 acts by trimming the C-terminal amino acids of tubulin and other substrates impacting their stability and function. This modification plays a role in determining microtubule dynamics which are important for cell shape division and intracellular transport.
Biological function summary

CCP1 contributes to maintaining cellular functions by removing glutamates from the C-terminal of tubulin impacting microtubule behavior. It forms part of the tubulin tyrosination-detyrosination cycle and interacts with other proteins within the cycle to regulate microtubule length and stability. This regulation is essential for the proper operation of neuronal cells and can influence processes like axonal transport and signaling.

Pathways

CCP1's enzymatic activity links to microtubule and cellular cytoskeleton organization pathways. It influences the dynamic instability of microtubules essential in cell division and intracellular traffic. CCP1 interacts with other tubulin-modifying enzymes like CCP5 which together modify microtubule attributes through polyglutamylation and serve roles in cell motility and structural integrity.

CCP1 alterations or mutations have associations with neurodegenerative disorders and certain forms of cancer. Its dysfunction can lead to the progressive degeneration of neurons connected to Ataxia a condition affecting motor control. Additionally CCP1 mutations or disruptions can link to tubulin-binding proteins contributing to unregulated cell proliferation seen in some cancers. Understanding CCP1's role in these conditions can guide therapeutic strategies targeting these proteins and pathways.
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Specifications

Form

Liquid

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General info

Function

Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins (PubMed : 22170066, PubMed : 24022482, PubMed : 30420557). Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin (PubMed : 22170066, PubMed : 24022482, PubMed : 30420557). Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate (PubMed : 24022482). Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of alpha-tubulin as well as non-tubulin proteins such as MYLK (PubMed : 22170066). Involved in KLF4 deglutamylation which promotes KLF4 proteasome-mediated degradation, thereby negatively regulating cell pluripotency maintenance and embryogenesis (PubMed : 29593216).

Sequence similarities

Belongs to the peptidase M14 family.

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Product protocols

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Target data

Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins (PubMed : 22170066, PubMed : 24022482, PubMed : 30420557). Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin (PubMed : 22170066, PubMed : 24022482, PubMed : 30420557). Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate (PubMed : 24022482). Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of alpha-tubulin as well as non-tubulin proteins such as MYLK (PubMed : 22170066). Involved in KLF4 deglutamylation which promotes KLF4 proteasome-mediated degradation, thereby negatively regulating cell pluripotency maintenance and embryogenesis (PubMed : 29593216).
See full target information AGTPBP1
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