Recombinant Human CCR4 protein (Tag Free)
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Recombinant Human CCR4 protein (Tag Free) is a Human Full Length protein, in the 1 to 360 aa range, expressed in Wheat germ, with >80%.
View Alternative Names
CD194, CMKBR4, CCR4, C-C chemokine receptor type 4, C-C CKR-4, CC-CKR-4, CCR-4, K5-5
Product details
Prepared in an in vitro wheat germ expression system with proprietary liposome technology. By using a mRNA having 5'cap and a poly(A)-tail with this extract in combination with a proprietary liposome, the translation reaction in vitro yields ample quantity of membrane protein which is captured by the liposome leading to correct conformation and folding essential for biological function.
Heating may cause protein aggregation. Please do not heat this product before electrophoresis.
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
CCR4 plays an important role in the trafficking of immune cells to inflammatory sites therefore regulating immune response and tolerance. It is part of the chemokine receptor family which is integral to the immune system's function. CCR4 helps maintain the balance between effector and regulatory T cells contributing to immunological homeostasis. Its involvement in migration and positioning of immune cells within lymphoid and peripheral tissues highlights its importance in maintaining immune surveillance.
Pathways
CCR4 significantly influences the chemokine signaling pathway which is pivotal in directing the movement and positioning of immune cells. This receptor interacts with key proteins like CCL17 and CCL22 to mediate cell chemotaxis in these pathways. Additionally CCR4 is associated with the T-cell receptor signaling pathway where it coordinates with other receptors and proteins to modulate immune responses.
Specifications
Form
Liquid
Additional notes
Glutathione Sepharose
General info
Function
High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.
Sequence similarities
Belongs to the G-protein coupled receptor 1 family.
Post-translational modifications
In natural killer cells, CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues, most probably by beta-adrenergic receptor kinases 1 and 2.
Target data
Complementary Products
Primary Antibodies
AB275400
Anti-CCR4 antibody [EPR23502-85] - BSA and Azide free
RabMAb|Recombinant
![Flow Cytometry - Anti-CCR4 antibody [EPR23502-85] - BSA and Azide free (AB275400)](https://content.abcam.com/products/images/ccr4-antibody-epr23502-85-bsa-and-azide-free-ab275400--flow-cytometry-img37376.jpg)
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Product promise
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