Recombinant Human CCR8 protein (VLPs) (Active)
- Bioactive
- What is this?
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Recombinant Human CCR8 protein (VLPs) (Active) is a Human Full Length protein, in the 1 to 355 aa range, expressed in Mammalian, < 1 EU/µg endotoxin level, suitable for WB, ELISA.
View Alternative Names
CDw198, CKRL1, CMKBR8, CMKBRL2, CCR8, C-C chemokine receptor type 8, C-C CKR-8, CC-CKR-8, CCR-8, CC chemokine receptor CHEMR1, Chemokine receptor-like 1, GPR-CY6, TER1, CKR-L1, GPRCY6
- I-ELISA
Supplier Data
Indirect ELISA - Recombinant Human CCR8 protein (VLPs) (Active) (AB300191)
ab300191 activity measured by its binding ability in a functional ELISA. Immobilized human CCR8 (ab300191) at 5 μg/ml can bind Anti-CCR8 recombinant antibody, the EC50 is 11.13-17.29 ng/ml.
- WB
Supplier Data
Western blot - Recombinant Human CCR8 protein (VLPs) (Active) (AB300191)
ab300191 is detected by Anti-CCR8 recombinant Antibody.
All lanes:
Western blot - Recombinant Human CCR8 protein (VLPs) (Active) (ab300191)
Predicted band size: 41 kDa
false
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
CCR8 plays a role in immune cell signaling and migration. This receptor interacts with its ligand CCL1 to mediate chemotaxis guiding cells to sites of inflammation or injury. CCR8 forms a part of the immune response machinery facilitating communication between cells. Through these interactions it influences the function of various immune cells such as regulatory T cells and supports the maintenance of immune homeostasis.
Pathways
CCR8 is involved in chemokine signaling pathways that regulate immune responses. It operates within the broader context of the chemokine receptor family including receptors like CCR4. These pathways are important for directing lymphocyte migration and are implicated in inflammation and immune surveillance processes. The engagement of CCR8 modulates downstream signaling events that influence T cell differentiation and immune cell recruitment.
Specifications
Form
Liquid
General info
Function
Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection.
Sequence similarities
Belongs to the G-protein coupled receptor 1 family.
Target data
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Product promise
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