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AB235076

Recombinant Human CCT2 protein (Tagged)

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Recombinant Human CCT2 protein (Tagged) is a Human Full Length protein, in the 2 to 535 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

View Alternative Names

99D8.1, CCTB, CCT2, T-complex protein 1 subunit beta, TCP-1-beta, CCT-beta, Chaperonin containing T-complex polypeptide 1 subunit 2

1 Images
SDS-PAGE - Recombinant Human CCT2 protein (Tagged) (AB235076)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human CCT2 protein (Tagged) (AB235076)

ab235076 analyzed by (Tris-Glycine gel) discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P78371

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.2 - 7.4 Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as TCP1 beta
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Sequence info

[{"sequence":"ASLSLAPVNIFKAGADEERAETARLTSFIGAIAIGDLVKSTLGPKGMDKILLSSGRDASLMVTNDGATILKNIGVDNPAAKVLVDMSRVQDDEVGDGTTSVTVLAAELLREAESLIAKKIHPQTIIAGWREATKAAREALLSSAVDHGSDEVKFRQDLMNIAGTTLSSKLLTHHKDHFTKLAVEAVLRLKGSGNLEAIHIIKKLGGSLADSYLDEGFLLDKKIGVNQPKRIENAKILIANTGMDTDKIKIFGSRVRVDSTAKVAEIEHAEKEKMKEKVERILKHGINCFINRQLIYNYPEQLFGAAGVMAIEHADFAGVERLALVTGGEIASTFDHPELVKLGSCKLIEEVMIGEDKLIHFSGVALGEACTIVLRGATQQILDEAERSLHDALCVLAQTVKDSRTVYGGGCSEMLMAHAVTQLANRTPGKEAVAMESYAKALRMLPTIIADNAGYDSADLVAQLRAAHSEGNTTAGLDMREGTIGDMAILGITESFQVKRQVLLSAAEAAEVILRVDNIIKAAPRKRVPDHHPC","proteinLength":"Full Length","predictedMolecularWeight":"73.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":535,"aminoAcidStart":2,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P78371","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CCT2 also known as Chaperonin Containing TCP1 Subunit 2 is part of a group of proteins responsible for facilitating the correct folding of other proteins. It functions as a molecular chaperone and has a molecular weight of approximately 58 kDa. CCT2 is expressed in many tissues with high levels detected in testis and brain tissues. This protein is integral to the chaperonin CCT (or TRiC) complex contributing to essential cellular processes through its role in protein homeostasis.
Biological function summary

CCT2 assists in the folding of cytoskeletal proteins like actin and tubulin which are vital for maintaining the structure and function of cells. As part of the CCT complex which consists of eight different subunits CCT2 plays a significant role in ensuring the proper assembly of multi-protein complexes. The activity of CCT2 is important for the prevention of aggregate formation which otherwise leads to cellular stress.

Pathways

CCT2 significantly influences the protein folding and degradation pathways. It participates in the cellular pathways that govern the proteostasis network collaborating with other chaperones to oversee protein quality control. Related proteins interacting with CCT2 within these pathways include other CCT complex components like CCT3 and CCT4 all contributing to maintaining cellular homeostasis and protecting cells from proteotoxic damage.

CCT2 is connected to cancer and neurodegenerative diseases. Altered expression of CCT2 is linked to the progression of tumor growth interacting with proteins involved in cell cycle regulation and signaling such as p53. Additionally deficits in CCT2 function can exacerbate protein misfolding disorders like Alzheimer's disease where proteins like tau become aggregated contributing to the pathology. Efforts to understand CCT2's role in these conditions highlight the importance of protein homeostasis in maintaining health.
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Specifications

Form

Liquid

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General info

Function

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed : 25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed : 25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed : 20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable).

Sequence similarities

Belongs to the TCP-1 chaperonin family.

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Product protocols

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Target data

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed : 25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed : 25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed : 20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable).
See full target information CCT2
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