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Recombinant human CD105 protein is a Human Fragment protein, in the 26 to 584 aa range, expressed in Insect, with >95% purity and suitable for ELISA, WB, SDS-PAGE.
Alternative names=Endoglin, ENG, END
>95% SDS-PAGE
Insect cells
His tag C-Terminus
ELISA, WB, SDS-PAGE
Yes
E T V H C D L Q P V G P E R G E V T Y T T S Q V S K G C V A Q A P N A I L E V H V L F L E F P T G P S Q L E L T L Q A S K Q N G T W P R E V L L V L S V N S S V F L H L Q A L G I P L H L A Y N S S L V T F Q E P P G V N T T E L P S F P K T Q I L E W A A E R G P I T S A A E L N D P Q S I L L R L G Q A Q G S L S F C M L E A S Q D M G R T L E W R P R T P A L V R G C H L E G V A G H K E A H I L R V L P G H S A G P R T V T V K V E L S C A P G D L D A V L I L Q G P P Y V S W L I D A N H N M Q I W T T G E Y S F K I F P E K N I R G F K L P D T P Q G L L G E A R M L N A S I V A S F V E L P L A S I V S L H A S S C G G R L Q T S P A P I Q T T P P K D T C S P E L L M S L I Q T K C A D D A M T L V L K K E L V A H L K C T I T G L T F W D P S C E A E D R G D K F V L R S A Y S S C G M Q V S A S M I S N E A V V N I L S S S S P Q R K K V H C L N M D S L S F Q L G L Y L S P H F L Q A S N T I E P G Q Q S F V Q V R V S P S V S E F L L Q L D S C H L D L G P E G G T V E L I Q G R A A K G N C V S L L S P S P E G D P R F S F L L H F Y T V P I P K T G T L S C T V A L R P K T G S Q D Q E V H R T V F M R L N I I S P D L S G C T S H H H H H H
Application | Reactivity | Dilution info | Notes |
---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes Ab54338 can be used as a WB positive control in conjunction with ab85956. |
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes This product has a calculated monomeric molecular mass of 61 kDa but as a result of glycosylation, migrates at approximately 75 - 85 kDa under reducing conditions in SDS-PAGE. |
Recombinant human CD105 protein is a Human Fragment protein, in the 26 to 584 aa range, expressed in Insect, with >95% purity and suitable for ELISA, WB, SDS-PAGE.
Alternative names=Endoglin, ENG, END
>95% SDS-PAGE
Insect cells
His tag C-Terminus
ELISA, WB, SDS-PAGE
Yes
Active
26 to 584
E T V H C D L Q P V G P E R G E V T Y T T S Q V S K G C V A Q A P N A I L E V H V L F L E F P T G P S Q L E L T L Q A S K Q N G T W P R E V L L V L S V N S S V F L H L Q A L G I P L H L A Y N S S L V T F Q E P P G V N T T E L P S F P K T Q I L E W A A E R G P I T S A A E L N D P Q S I L L R L G Q A Q G S L S F C M L E A S Q D M G R T L E W R P R T P A L V R G C H L E G V A G H K E A H I L R V L P G H S A G P R T V T V K V E L S C A P G D L D A V L I L Q G P P Y V S W L I D A N H N M Q I W T T G E Y S F K I F P E K N I R G F K L P D T P Q G L L G E A R M L N A S I V A S F V E L P L A S I V S L H A S S C G G R L Q T S P A P I Q T T P P K D T C S P E L L M S L I Q T K C A D D A M T L V L K K E L V A H L K C T I T G L T F W D P S C E A E D R G D K F V L R S A Y S S C G M Q V S A S M I S N E A V V N I L S S S S P Q R K K V H C L N M D S L S F Q L G L Y L S P H F L Q A S N T I E P G Q Q S F V Q V R V S P S V S E F L L Q L D S C H L D L G P E G G T V E L I Q G R A A K G N C V S L L S P S P E G D P R F S F L L H F Y T V P I P K T G T L S C T V A L R P K T G S Q D Q E V H R T V F M R L N I I S P D L S G C T S H H H H H H
Fragment
No
Recombinant
Human
Reconstitute in PBS or medium to a concentration not lower than 50 µg/ml.
Lyophilized
Purity: > 95% (SDS-PAGE and visualized by Silverstain). Affinity purified.
Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis (PubMed:21737454, PubMed:23300529). Required for normal structure and integrity of adult vasculature (PubMed:7894484). Regulates the migration of vascular endothelial cells (PubMed:17540773). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors (PubMed:1692830). Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed:8370410, PubMed:21737454, PubMed:22347366, PubMed:23300529). Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (PubMed:21737454, PubMed:22347366, PubMed:23300529).
Blue Ice
-20°C
Avoid freeze / thaw cycle
This product is an active protein and may elicit a biological response in vivo, handle with caution.
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