Recombinant human CD134 / OX40L receptor protein (Fc Chimera Active) is a Human Fragment protein, in the 29 to 216 aa range, expressed in HEK 293, with >90% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE, FuncS, ELISA.
>90% SDS-PAGE
HEK 293 cells
Fc tag C-Terminus
SDS-PAGE, FuncS, ELISA
Yes
L H C V G D T Y P S N D R C C H E C R P G N G M V S R C S R S Q N T V C R P C G P G F Y N D V V S S K P C K P C T W C N L R S G S E R K Q L C T A T Q D T V C R C R A G T Q P L D S Y K P G V D C A P C P P G H F S P G D N Q A C K P W T N C T L A G K H T L Q P A S N S S D A I C E D R D P P A T Q P Q E T Q G P P A R P I T V Q P T E A W P R T S Q G P S T R P V E V P G G R A V A P K S C D K T H T C P P C P A P E L L G G P S V F L F P P K P K D T L M I S R T P E V T C V V V D V S H E D P E V K F N W Y V D G V E V H N A K T K P R E E Q Y N S T Y R V V S V L T V L H Q D W L N G K E Y K C K V S N K A L P A P I E K T I S K A K G Q P R E P Q V Y T L P P S R D E L T K N Q V S L T C L V K G F Y P S D I A V E W E S N G Q P E N N Y K T T P P V L D S D G S F F L Y S K L T V D K S R W Q Q G N V F S C S V M H E A L H N H Y T Q K S L S L S P G K
Application | Reactivity | Dilution info | Notes |
---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application FuncS | Reactivity Reacts | Dilution info - | Notes - |
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Select an associated product type
Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity.(Microbial infection) Acts as a receptor for human herpesvirus 6B/HHV-6B.
TXGP1L, TNFRSF4, Tumor necrosis factor receptor superfamily member 4, ACT35 antigen, OX40L receptor, TAX transcriptionally-activated glycoprotein 1 receptor
Recombinant human CD134 / OX40L receptor protein (Fc Chimera Active) is a Human Fragment protein, in the 29 to 216 aa range, expressed in HEK 293, with >90% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE, FuncS, ELISA.
>90% SDS-PAGE
HEK 293 cells
Fc tag C-Terminus
SDS-PAGE, FuncS, ELISA
Yes
Measured by its binding ability in a functional ELISA Immobilized Recombinant human OX40L/TNFSF4 protein (His tag) (ab221412) at 5 μg/mL (100 μL/well) can bind ab221340 with a linear range of 2-25 ng/mL.
No
Human
Reconstitute at 400 µg/mL in water
pH: 7.4
Constituents: 5% Trehalose, 0.87% Sodium chloride, 0.75% Glycine, 0.61% Tris, 0.44% L-Arginine
L H C V G D T Y P S N D R C C H E C R P G N G M V S R C S R S Q N T V C R P C G P G F Y N D V V S S K P C K P C T W C N L R S G S E R K Q L C T A T Q D T V C R C R A G T Q P L D S Y K P G V D C A P C P P G H F S P G D N Q A C K P W T N C T L A G K H T L Q P A S N S S D A I C E D R D P P A T Q P Q E T Q G P P A R P I T V Q P T E A W P R T S Q G P S T R P V E V P G G R A V A P K S C D K T H T C P P C P A P E L L G G P S V F L F P P K P K D T L M I S R T P E V T C V V V D V S H E D P E V K F N W Y V D G V E V H N A K T K P R E E Q Y N S T Y R V V S V L T V L H Q D W L N G K E Y K C K V S N K A L P A P I E K T I S K A K G Q P R E P Q V Y T L P P S R D E L T K N Q V S L T C L V K G F Y P S D I A V E W E S N G Q P E N N Y K T T P P V L D S D G S F F L Y S K L T V D K S R W Q Q G N V F S C S V M H E A L H N H Y T Q K S L S L S P G K
Fragment
46.8 kDa
29 to 216
Recombinant
Fc tag C-Terminus
Lyophilized
Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity.
Blue Ice
-20°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
This product is an active protein and may elicit a biological response in vivo, handle with caution.
This product is stable after storage at:
This supplementary information is collated from multiple sources and compiled automatically.
CD134 also known as OX40 or TNFRSF4 is a receptor that plays an essential role in immune response regulation. This receptor is part of the tumor necrosis factor receptor (TNFR) superfamily and has a molecular mass of approximately 50 kDa. CD134 is expressed on activated T cells particularly CD4+ T cells and is present on various other immune cells under specific conditions. The receptor binds to the OX40L its ligand which is expressed on antigen-presenting cells such as dendritic cells and B cells.
CD134 influences T cell proliferation survival and memory formation being an important component of the immune system's adaptive response. OX40L engagement with CD134 enhances the activation and survival of T cells promoting long-term immunity. This interaction does not form part of a larger complex but functions as a direct signaling mechanism that augments T cell receptor (TCR) signaling leading to increased cytokine production and sustained immune responses essential for controlling infections and cancer.
CD134 signaling intersects with the nuclear factor-kappa B (NF-κB) and phosphoinositide 3-kinase (PI3K) pathways. These pathways play significant roles in regulating immune responses and cell survival. Through the NF-κB pathway CD134 influences gene transcription related to immune activation. It also connects with other immune regulatory proteins such as CD28 which further potentiates T cell responses and enhances effector functions.
CD134 has connections to autoimmune diseases and cancers. Overactivity of the CD134-OX40L pathway can lead to exacerbated autoimmune conditions such as lupus. This receptor has also been implicated in tumor immunity where its activation enhances the anti-tumor response of T cells. CD134 interacts with CTLA-4 another immune checkpoint protein playing a role in balancing immune activation and regulation within these disease contexts.
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Terms & Conditions.
Immobilized Recombinant human OX40L/TNFSF4 protein (His tag) (ab221412) at 5 μg/mL (100 μL/well) can bind ab221340 with a linear range of 2-25 ng/mL.
FACS assay shows that recombinant Human OX40, Fc Tag can bind to 293T cell overexpressing human OX40L. The concentration of OX40 used is 0.03 µg/ml.
SDS PAGE analysis of ab221340. The gel was stained overnight with Coomassie Blue. Due to glycosylation, the protein migrates at 65 kDa under reducing conditions.
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