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Recombinant Human CD134 / OX40L receptor Protein (His-tag) (Active) is a Human Fragment protein, in the 29 to 216 aa range, expressed in HEK 293, with >=95% purity, <= 0.005 EU/µg endotoxin level and suitable for HPLC, SDS-PAGE.

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Images

HPLC - Recombinant Human CD134 / OX40L receptor Protein (His-tag) (Active) (AB307791), expandable thumbnail
  • SDS-PAGE - Recombinant Human CD134 / OX40L receptor Protein (His-tag) (Active) (AB307791), expandable thumbnail
  • Biological Activity - Recombinant Human CD134 / OX40L receptor Protein (His-tag) (Active) (AB307791), expandable thumbnail

Key facts

Purity

>=95% HPLC

Endotoxin level

<= 0.005 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

HPLC, SDS-PAGE

Biologically active

Yes

Amino acid sequence

L H C V G D T Y P S N D R C C H E C R P G N G M V S R C S R S Q N T V C R P C G P G F Y N D V V S S K P C K P C T W C N L R S G S E R K Q L C T A T Q D T V C R C R A G T Q P L D S Y K P G V D C A P C P P G H F S P G D N Q A C K P W T N C T L A G K H T L Q P A S N S S D A I C E D R D P P A T Q P Q E T Q G P P A R P I T V Q P T E A W P R T S Q G P S T R P V E V P G G R A V A

Reactivity data

Application

HPLC

Reactivity

Reacts

Dilution info

-

Notes

-

Application

SDS-PAGE

Reactivity

Reacts

Dilution info

-

Notes

-

Target data

Function

Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity.(Microbial infection) Acts as a receptor for human herpesvirus 6B/HHV-6B.

Alternative names

Recommended products

Recombinant Human CD134 / OX40L receptor Protein (His-tag) (Active) is a Human Fragment protein, in the 29 to 216 aa range, expressed in HEK 293, with >=95% purity, <= 0.005 EU/µg endotoxin level and suitable for HPLC, SDS-PAGE.

Key facts

Purity

>=95% HPLC

Endotoxin level

<= 0.005 EU/µg

Expression system

HEK 293 cells

Applications

HPLC, SDS-PAGE

Biological activity

Loaded Human OX40, Human Fc Tag on Protein A Biosensor can bind Human OX40L receptor/CD134, His Tag with an affinity constant of 3.9 uM as determined in BLI assay (GatorBio Prime). 

Accession
P43489-1
Animal free

Yes

Species

Human

Reconstitution

Reconstitute in PBS

Concentration
Loading...
Storage buffer

pH: 7.4
Constituents: 10.26% Trehalose, 0.727% Dibasic monohydrogen potassium phosphate, 0.248% Potassium phosphate monobasic

Sequence info

Amino acid sequence

L H C V G D T Y P S N D R C C H E C R P G N G M V S R C S R S Q N T V C R P C G P G F Y N D V V S S K P C K P C T W C N L R S G S E R K Q L C T A T Q D T V C R C R A G T Q P L D S Y K P G V D C A P C P P G H F S P G D N Q A C K P W T N C T L A G K H T L Q P A S N S S D A I C E D R D P P A T Q P Q E T Q G P P A R P I T V Q P T E A W P R T S Q G P S T R P V E V P G G R A V A

Accession

P43489

Protein length

Fragment

Predicted molecular weight

21.67 kDa

Amino acids

29 to 216

Nature

Recombinant

Tags

His tag C-Terminus

Specifications

Form

Lyophilized

Additional notes

SDS-PAGE >= 95%

General info

Function

Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity.

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

Ambient

Appropriate long-term storage conditions

Ambient

This product is an active protein and may elicit a biological response in vivo, handle with caution.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

CD134 also known as OX40 or TNFRSF4 is a receptor that plays an essential role in immune response regulation. This receptor is part of the tumor necrosis factor receptor (TNFR) superfamily and has a molecular mass of approximately 50 kDa. CD134 is expressed on activated T cells particularly CD4+ T cells and is present on various other immune cells under specific conditions. The receptor binds to the OX40L its ligand which is expressed on antigen-presenting cells such as dendritic cells and B cells.

Biological function summary

CD134 influences T cell proliferation survival and memory formation being an important component of the immune system's adaptive response. OX40L engagement with CD134 enhances the activation and survival of T cells promoting long-term immunity. This interaction does not form part of a larger complex but functions as a direct signaling mechanism that augments T cell receptor (TCR) signaling leading to increased cytokine production and sustained immune responses essential for controlling infections and cancer.

Pathways

CD134 signaling intersects with the nuclear factor-kappa B (NF-κB) and phosphoinositide 3-kinase (PI3K) pathways. These pathways play significant roles in regulating immune responses and cell survival. Through the NF-κB pathway CD134 influences gene transcription related to immune activation. It also connects with other immune regulatory proteins such as CD28 which further potentiates T cell responses and enhances effector functions.

Associated diseases and disorders

CD134 has connections to autoimmune diseases and cancers. Overactivity of the CD134-OX40L pathway can lead to exacerbated autoimmune conditions such as lupus. This receptor has also been implicated in tumor immunity where its activation enhances the anti-tumor response of T cells. CD134 interacts with CTLA-4 another immune checkpoint protein playing a role in balancing immune activation and regulation within these disease contexts.

Product promise

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In the unlikely event of one of our products not working as expected, you are covered by our product promise.

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3 product images

  • HPLC - Recombinant Human CD134 / OX40L receptor Protein (His-tag) (Active) (ab307791), expandable thumbnail

    HPLC - Recombinant Human CD134 / OX40L receptor Protein (His-tag) (Active) (ab307791)

    HPLC analysis of ab307791

  • SDS-PAGE - Recombinant Human CD134 / OX40L receptor Protein (His-tag) (Active) (ab307791), expandable thumbnail

    SDS-PAGE - Recombinant Human CD134 / OX40L receptor Protein (His-tag) (Active) (ab307791)

    SDS-PAGE analysis of ab307791

  • Biological Activity - Recombinant Human CD134 / OX40L receptor Protein (His-tag) (Active) (ab307791), expandable thumbnail

    Biological Activity - Recombinant Human CD134 / OX40L receptor Protein (His-tag) (Active) (ab307791)

    Loaded Human OX40, Human Fc Tag on Protein A Biosensor can bind Human OX40L receptor/CD134, His Tag with an affinity constant of 3.9 uM as determined in BLI assay (GatorBio Prime).

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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