Recombinant Human CD134 / OX40L receptor protein (Tagged) (Biotin) is a Human Fragment protein, in the 29 to 216 aa range, expressed in HEK 293, with >=90% purity and suitable for SDS-PAGE.
Images
Key facts
- Purity
- >=90% SDS-PAGE
- Expression system
- HEK 293 cells
- Tags
- Avi tag C-Terminus His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Conjugation
- Biotin
Amino acid sequence
V I T T P L E T V D A L V E E V A T F M C A V E S Y P Q P E I S W T R N K I L I K L F D T R Y S I R E N G Q L L T I L S V E D S D D G I Y C C T A N N G V G G A V E S C G A L Q V K M K P K I T R P P I N V K I I E G L K A V L P C T T M G N P K P S V S W I K G D S P L R E N S R I A V L E S G S L R I H N V Q K E D A G Q Y R C V A K N S L G T A Y S K V V K L E V E V F A R I L R
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes This protein runs at a higher MW by SDS-PAGE due to glycosylation. |
Target data
Function
Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity. (Microbial infection) Acts as a receptor for human herpesvirus 6B/HHV-6B.
Alternative names
CD134, TXGP1L, TNFRSF4, Tumor necrosis factor receptor superfamily member 4, ACT35 antigen, OX40L receptor, TAX transcriptionally-activated glycoprotein 1 receptor
Recommended products
Recombinant Human CD134 / OX40L receptor protein (Tagged) (Biotin) is a Human Fragment protein, in the 29 to 216 aa range, expressed in HEK 293, with >=90% purity and suitable for SDS-PAGE.
Key facts
- Purity
- >=90% SDS-PAGE
- Expression system
- HEK 293 cells
- Tags
- Avi tag C-Terminus His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Conjugation
- Biotin
- Accession
- P43489-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 7.4
Constituents: 20% Glycerol (glycerin, glycerine), 0.64% Sodium chloride, 0.13% Sodium phosphate, 0.02% Potassium chloride
Sequence info
Amino acid sequence
- V I T T P L E T V D A L V E E V A T F M C A V E S Y P Q P E I S W T R N K I L I K L F D T R Y S I R E N G Q L L T I L S V E D S D D G I Y C C T A N N G V G G A V E S C G A L Q V K M K P K I T R P P I N V K I I E G L K A V L P C T T M G N P K P S V S W I K G D S P L R E N S R I A V L E S G S L R I H N V Q K E D A G Q Y R C V A K N S L G T A Y S K V V K L E V E V F A R I L R
- Accession
- P43489
- Protein length
- Fragment
- Predicted molecular weight
- 23.6 kDa
- Amino acids
- 29 to 216
- Nature
- Recombinant
- Tags
- Avi tag C-Terminus, His tag C-Terminus
Specifications
- Form
- Liquid
General info
- Function
Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity.
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Storage information
- Avoid freeze / thaw cycle, Store in the dark
Notes
Enzymatically biotin-labeled using Avi-tag™ technology
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
CD134 also known as OX40 or TNFRSF4 is a receptor that plays an essential role in immune response regulation. This receptor is part of the tumor necrosis factor receptor (TNFR) superfamily and has a molecular mass of approximately 50 kDa. CD134 is expressed on activated T cells particularly CD4+ T cells and is present on various other immune cells under specific conditions. The receptor binds to the OX40L its ligand which is expressed on antigen-presenting cells such as dendritic cells and B cells.
- Biological function summary
CD134 influences T cell proliferation survival and memory formation being an important component of the immune system's adaptive response. OX40L engagement with CD134 enhances the activation and survival of T cells promoting long-term immunity. This interaction does not form part of a larger complex but functions as a direct signaling mechanism that augments T cell receptor (TCR) signaling leading to increased cytokine production and sustained immune responses essential for controlling infections and cancer.
- Pathways
CD134 signaling intersects with the nuclear factor-kappa B (NF-κB) and phosphoinositide 3-kinase (PI3K) pathways. These pathways play significant roles in regulating immune responses and cell survival. Through the NF-κB pathway CD134 influences gene transcription related to immune activation. It also connects with other immune regulatory proteins such as CD28 which further potentiates T cell responses and enhances effector functions.
- Associated diseases and disorders
CD134 has connections to autoimmune diseases and cancers. Overactivity of the CD134-OX40L pathway can lead to exacerbated autoimmune conditions such as lupus. This receptor has also been implicated in tumor immunity where its activation enhances the anti-tumor response of T cells. CD134 interacts with CTLA-4 another immune checkpoint protein playing a role in balancing immune activation and regulation within these disease contexts.
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1 product image
SDS-PAGE - Recombinant Human CD134 / OX40L receptor protein (Tagged) (Biotin) (ab271641)
SDS-PAGE analysis of 3 μg ab271641.
This protein runs at a higher MW by SDS-PAGE due to glycosylation.
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