Recombinant Human CD137 protein (Active) is a Human Fragment protein, in the 24 to 186 aa range, <= 0.005 EU/µg endotoxin level and suitable for SDS-PAGE, MS.
Images
Key facts
- Purity
- HPLC
- Endotoxin level
- <= 0.005 EU/µg
- Tags
- Tag free
- Applications
- SDS-PAGE, MS
- Biologically active
- Yes
Amino acid sequence
L Q D P C S N C P A G T F C D N N R N Q I C S P C P P N S F S S A G G Q R T C D I C R Q C K G V F R T R K E C S S T S N A E C D C T P G F H C L G A G C S M C E Q D C K Q G Q E L T K K G C K D C C F G T F N D Q K R G I C R P W T N C S L D G K S V L V N G T K E R D V V C G P S P A D L S P G A S S V T P P A P A R E P G H S P Q
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Receptor for TNFSF9/4-1BBL. Conveys a signal that enhances CD8(+) T-cell survival, cytotoxicity, and mitochondrial activity, thereby promoting immunity against viruses and tumors (Probable).
Alternative names
CD137, ILA, TNFRSF9, Tumor necrosis factor receptor superfamily member 9, 4-1BB ligand receptor, CDw137, T-cell antigen 4-1BB homolog, T-cell antigen ILA
Recommended products
Recombinant Human CD137 protein (Active) is a Human Fragment protein, in the 24 to 186 aa range, <= 0.005 EU/µg endotoxin level and suitable for SDS-PAGE, MS.
Key facts
- Purity
- HPLC
- Endotoxin level
- <= 0.005 EU/µg
- Tags
- Tag free
- Applications
- SDS-PAGE, MS
- Biologically active
- Yes
- Biological activity
- Fully biologically active determined by the dose dependent inhibition of anti-4-1BB antibody mediated activation of genetically engineered Jurkat T cell coexpressing 4-1BB and a responsive reporter element in presence of FcgammaRIIb CHO-K1 cells.
ED50 is ≤ 126.7 ng/ml, corresponding to a specific activity of 7.9 x 103 units/mg.
- Accession
- Q07011-1
- Animal free
- Yes
- Species
- Human
- Reconstitution
- Reconstitute in PBS
- Concentration
- Storage buffer
pH: 7.4
Constituents: 10.26% Trehalose, 0.727% Dibasic monohydrogen potassium phosphate, 0.248% Potassium phosphate monobasic
Sequence info
Amino acid sequence
- L Q D P C S N C P A G T F C D N N R N Q I C S P C P P N S F S S A G G Q R T C D I C R Q C K G V F R T R K E C S S T S N A E C D C T P G F H C L G A G C S M C E Q D C K Q G Q E L T K K G C K D C C F G T F N D Q K R G I C R P W T N C S L D G K S V L V N G T K E R D V V C G P S P A D L S P G A S S V T P P A P A R E P G H S P Q
- Accession
- Q07011
- Protein length
- Fragment
- Predicted molecular weight
- 17.3 kDa
- Actual molecular weight
- 17.3 kDa
- Amino acids
- 24 to 186
- Nature
- Recombinant
Specifications
- Form
- Lyophilized
General info
- Function
Receptor for TNFSF9/4-1BBL. Conveys a signal that enhances CD8(+) T-cell survival, cytotoxicity, and mitochondrial activity, thereby promoting immunity against viruses and tumors (Probable).
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- Ambient
- Appropriate long-term storage conditions
- Ambient
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
CD137 also known as 4-1BB or TNFRSF9 is a protein that functions as a costimulatory receptor in the immune system. It belongs to the tumor necrosis factor receptor (TNFR) superfamily. CD137 has a mass of approximately 30 kDa. Expression of CD137 occurs mainly on activated T lymphocytes including both CD8+ and CD4+ T cells as well as natural killer (NK) cells dendritic cells and monocytes. The CD137 ligand (CD137L) is the counterpart that engages this receptor transmitting signals important for immune response regulation.
- Biological function summary
CD137 plays an important role in T cell activation and survival. It is a member of a receptor-ligand system that enhances immune cell functions. CD137 is part of a receptor complex that when bound by its ligand CD137L promotes cell proliferation and cytokine production. It also supports the development of memory T cells contributing to the body's ability to mount long-term immune responses.
- Pathways
CD137 takes part in the NF-kB signaling and MAPK pathways. These pathways are vital for regulating immune responses and inflammation. CD137 signaling through these pathways involves interaction with proteins such as TRAF1 and TRAF2 which help mediate downstream effects critical for cell survival and proliferation. These interactions enhance the body's defense against pathogens and tumors.
- Associated diseases and disorders
CD137 is associated with cancer immunotherapy and autoimmune diseases. In cancer CD137 enhances the anti-tumor activity of immune cells making it a target for immunotherapy strategies. For autoimmune diseases abnormal CD137 expression can lead to excessive immune responses contributing to disease pathogenesis. The protein is also connected to TNF-alpha through its involvement in inflammation suggesting potential intervention points for modulating immune response in related diseases.
Product promise
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
1 product image
Biological Activity - Recombinant Human CD137 protein (Active) (ab287936)
Fully biologically active determined by the dose dependent inhibition of anti-4-1BB antibody mediated activation of genetically engineered Jurkat T cell coexpressing 4-1BB and a responsive reporter element in presence of FcgammaRIIb CHO-K1 cells.
ED50 is ≤ 126.7 ng/ml, corresponding to a specific activity of 7.9 x 103 units/mg.
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com