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BiochemicalsProteins and Peptides
Proteins and peptidesAnti-Ly6g antibody [1A8] - mouse IgG2c (Chimeric)
Low endotoxin, Azide free.
Our first-to-market chimera with mouse IgG2c backbone, this functional antibody specifically depletes neutrophils in vivo for up to 72h.
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Recombinant Human CD137 protein (Biotin) is a Human Fragment protein, in the 24 to 186 aa range, expressed in HEK 293, with >=90% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
>=90% SDS-PAGE
< 1 EU/µg
HEK 293 cells
Tag free
SDS-PAGE
No
Biotin
L Q D P C S N C P A G T F C D N N R N Q I C S P C P P N S F S S A G G Q R T C D I C R Q C K G V F R T R K E C S S T S N A E C D C T P G F H C L G A G C S M C E Q D C K Q G Q E L T K K G C K D C C F G T F N D Q K R G I C R P W T N C S L D G K S V L V N G T K E R D V V C G P S P A D L S P G A S S V T P P A P A R E P G H S P Q
Application | Reactivity | Dilution info | Notes |
---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes ab198465 runs at a higher MW by SDS-PAGE due to glycosylation. |
Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.
Tumor necrosis factor receptor superfamily member 9, 4-1BB ligand receptor, CDw137, T-cell antigen 4-1BB homolog, T-cell antigen ILA, TNFRSF9, ILA, CD137
Recombinant Human CD137 protein (Biotin) is a Human Fragment protein, in the 24 to 186 aa range, expressed in HEK 293, with >=90% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
Tumor necrosis factor receptor superfamily member 9, 4-1BB ligand receptor, CDw137, T-cell antigen 4-1BB homolog, T-cell antigen ILA, TNFRSF9, ILA, CD137
>=90% SDS-PAGE
< 1 EU/µg
HEK 293 cells
Tag free
SDS-PAGE
No
Biotin
No
Human
pH: 7.4
Constituents: 20% Glycerol (glycerin, glycerine), 0.64% Sodium chloride, 0.63% Tris HCl, 0.02% Potassium chloride
L Q D P C S N C P A G T F C D N N R N Q I C S P C P P N S F S S A G G Q R T C D I C R Q C K G V F R T R K E C S S T S N A E C D C T P G F H C L G A G C S M C E Q D C K Q G Q E L T K K G C K D C C F G T F N D Q K R G I C R P W T N C S L D G K S V L V N G T K E R D V V C G P S P A D L S P G A S S V T P P A P A R E P G H S P Q
Fragment
45.9 kDa
24 to 186
Recombinant
Liquid
Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.
Dry Ice
-80°C
Avoid freeze / thaw cycle
ab198465 is useful for studying protein binding and screening small molecules.
CD137 plays an important role in T cell activation and survival. It is a member of a receptor-ligand system that enhances immune cell functions. CD137 is part of a receptor complex that when bound by its ligand CD137L promotes cell proliferation and cytokine production. It also supports the development of memory T cells contributing to the body's ability to mount long-term immune responses.
CD137 also known as 4-1BB or TNFRSF9 is a protein that functions as a costimulatory receptor in the immune system. It belongs to the tumor necrosis factor receptor (TNFR) superfamily. CD137 has a mass of approximately 30 kDa. Expression of CD137 occurs mainly on activated T lymphocytes including both CD8+ and CD4+ T cells as well as natural killer (NK) cells dendritic cells and monocytes. The CD137 ligand (CD137L) is the counterpart that engages this receptor transmitting signals important for immune response regulation.
CD137 takes part in the NF-kB signaling and MAPK pathways. These pathways are vital for regulating immune responses and inflammation. CD137 signaling through these pathways involves interaction with proteins such as TRAF1 and TRAF2 which help mediate downstream effects critical for cell survival and proliferation. These interactions enhance the body's defense against pathogens and tumors.
CD137 is associated with cancer immunotherapy and autoimmune diseases. In cancer CD137 enhances the anti-tumor activity of immune cells making it a target for immunotherapy strategies. For autoimmune diseases abnormal CD137 expression can lead to excessive immune responses contributing to disease pathogenesis. The protein is also connected to TNF-alpha through its involvement in inflammation suggesting potential intervention points for modulating immune response in related diseases.
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Full details and terms and conditions can be found here:
Terms & Conditions.
4-20% SDS PAGE analysis of 2.8 μg ab198465 stained with Coomassie.
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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