Skip to main content

Recombinant Human CD137 protein (Biotin) is a Human Fragment protein, in the 24 to 186 aa range, expressed in HEK 293, with >=90% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.

Be the first to review this product! Submit a review

Images

Key facts

Purity

>=90% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

Tag free

Applications

SDS-PAGE

Biologically active

No

Conjugation

Biotin

Amino acid sequence

L Q D P C S N C P A G T F C D N N R N Q I C S P C P P N S F S S A G G Q R T C D I C R Q C K G V F R T R K E C S S T S N A E C D C T P G F H C L G A G C S M C E Q D C K Q G Q E L T K K G C K D C C F G T F N D Q K R G I C R P W T N C S L D G K S V L V N G T K E R D V V C G P S P A D L S P G A S S V T P P A P A R E P G H S P Q

Loading...
Loading...
Loading...
Loading...
Loading...
Loading...
Loading...
Loading...

Reactivity data

Application

SDS-PAGE

Reactivity

Reacts

Dilution info

-

Notes

ab198465 runs at a higher MW by SDS-PAGE due to glycosylation.

Target data

Function

Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.

Alternative names

Recommended products

  1. Loading...
  2. Loading...
  3. Loading...
  4. Loading...

Recombinant Human CD137 protein (Biotin) is a Human Fragment protein, in the 24 to 186 aa range, expressed in HEK 293, with >=90% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.

Alternative names

Key facts

Purity

>=90% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Applications

SDS-PAGE

Conjugation

Biotin

Accession
Q07011-1
Animal free

No

Species

Human

Concentration
Loading...
Storage buffer

pH: 7.4
Constituents: 20% Glycerol (glycerin, glycerine), 0.64% Sodium chloride, 0.63% Tris HCl, 0.02% Potassium chloride

Sequence info

Amino acid sequence

L Q D P C S N C P A G T F C D N N R N Q I C S P C P P N S F S S A G G Q R T C D I C R Q C K G V F R T R K E C S S T S N A E C D C T P G F H C L G A G C S M C E Q D C K Q G Q E L T K K G C K D C C F G T F N D Q K R G I C R P W T N C S L D G K S V L V N G T K E R D V V C G P S P A D L S P G A S S V T P P A P A R E P G H S P Q

Accession

Q07011

Protein length

Fragment

Predicted molecular weight

45.9 kDa

Amino acids

24 to 186

Nature

Recombinant

Specifications

Form

Liquid

General info

Function

Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.

Storage

Shipped at conditions

Dry Ice

Appropriate long-term storage conditions

-80°C

Storage information

Avoid freeze / thaw cycle

Notes

ab198465 is useful for studying protein binding and screening small molecules.

Supplementary info

Biological function summary

CD137 plays an important role in T cell activation and survival. It is a member of a receptor-ligand system that enhances immune cell functions. CD137 is part of a receptor complex that when bound by its ligand CD137L promotes cell proliferation and cytokine production. It also supports the development of memory T cells contributing to the body's ability to mount long-term immune responses.

Activity summary

CD137 also known as 4-1BB or TNFRSF9 is a protein that functions as a costimulatory receptor in the immune system. It belongs to the tumor necrosis factor receptor (TNFR) superfamily. CD137 has a mass of approximately 30 kDa. Expression of CD137 occurs mainly on activated T lymphocytes including both CD8+ and CD4+ T cells as well as natural killer (NK) cells dendritic cells and monocytes. The CD137 ligand (CD137L) is the counterpart that engages this receptor transmitting signals important for immune response regulation.

Pathways

CD137 takes part in the NF-kB signaling and MAPK pathways. These pathways are vital for regulating immune responses and inflammation. CD137 signaling through these pathways involves interaction with proteins such as TRAF1 and TRAF2 which help mediate downstream effects critical for cell survival and proliferation. These interactions enhance the body's defense against pathogens and tumors.

Associated diseases and disorders

CD137 is associated with cancer immunotherapy and autoimmune diseases. In cancer CD137 enhances the anti-tumor activity of immune cells making it a target for immunotherapy strategies. For autoimmune diseases abnormal CD137 expression can lead to excessive immune responses contributing to disease pathogenesis. The protein is also connected to TNF-alpha through its involvement in inflammation suggesting potential intervention points for modulating immune response in related diseases.

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

1 product image

  • SDS-PAGE - Recombinant Human CD137 protein (Biotin) (ab198465), expandable thumbnail

    SDS-PAGE - Recombinant Human CD137 protein (Biotin) (ab198465)

    4-20% SDS PAGE analysis of 2.8 μg ab198465 stained with Coomassie.

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

There was a problem

We can’t download that datasheet. Please try again. If you need help, contact our Customer Services team at technical@abcam.com