Recombinant Human CD168 protein is a Human Fragment protein, in the 184 to 438 aa range, expressed in Escherichia coli, with >50% purity and suitable for SDS-PAGE.
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Receptor for hyaluronic acid (HA) (By similarity). Involved in cell motility (By similarity). When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity. May act as a regulator of adipogenisis (By similarity).
CD168, IHABP, RHAMM, HMMR, Hyaluronan mediated motility receptor, Intracellular hyaluronic acid-binding protein, Receptor for hyaluronan-mediated motility
Recombinant Human CD168 protein is a Human Fragment protein, in the 184 to 438 aa range, expressed in Escherichia coli, with >50% purity and suitable for SDS-PAGE.
Constituents: 0.58% Sodium chloride, 0.32% Tris HCl
Purified via His tag
Receptor for hyaluronic acid (HA) (By similarity). Involved in cell motility (By similarity). When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity. May act as a regulator of adipogenisis (By similarity).
CD168 also known as HMMR (hyaluronan-mediated motility receptor) is a protein that functions mechanically as a receptor involved in cell motility proliferation and adhesion. Its molecular weight is approximately 95 kDa. CD168 expression can be prominently found in tissues that contain a high density of hyaluronan such as tumor cells and certain types of epithelial cells. Additionally CD168 is often used as a marker for certain macrophage populations illustrating its role in the immune landscape.
Hyaluronan-mediated motility receptor plays an important role in the regulation of the extracellular matrix (ECM) by binding to hyaluronan a significant component of the ECM. CD168 has a vital function in cell surface signaling processes facilitating communication between cells and their environment. The protein operates in a complex with elements like growth factor receptors enhancing its ability to modulate cellular responses. This interaction allows CD168 to significantly influence processes like wound healing and tissue remodeling.
Hyaluronan-mediated motility receptor participates in the Rho signaling pathway important for cytoskeletal organization and cell movement. Through this pathway CD168 interacts directly with proteins such as GTPases including members of the Rho family like RhoA which play key roles in the reorganization of the actin cytoskeleton. CD168 also relates to the PI3K/AKT pathway influencing cellular survival and proliferation by interacting with proteins such as PI3K integrally involved in cellular growth and response to extracellular signals.
Increased expression of hyaluronan-mediated motility receptor has been observed in several cancers including breast and ovarian cancers where it often correlates with advanced disease stages and poor prognosis. CD168's role in cancer is linked with its interaction with the epidermal growth factor receptor (EGFR) which promotes aggressive tumor behavior. In arthritis CD168 expression contributes to synovial inflammation connecting with inflammatory cytokines that escalate the disease progression. These associations underline the importance of CD168 in both oncology and inflammatory disorders.
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