Recombinant Human CD172 gamma protein is a Human Fragment protein, in the 29 to 364 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
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Key facts
- Purity
- >95% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- Tag free
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
E E E L Q M I Q P E K L L L V T V G K T A T L H C T V T S L L P V G P V L W F R G V G P G R E L I Y N Q K E G H F P R V T T V S D L T K R N N M D F S I R I S S I T P A D V G T Y Y C V K F R K G S P E N V E F K S G P G T E M A L G A K P S A P V V L G P A A R T T P E H T V S F T C E S H G F S P R D I T L K W F K N G N E L S D F Q T N V D P T G Q S V A Y S I R S T A R V V L D P W D V R S Q V I C E V A H V T L Q G D P L R G T A N L S E A I R V P P T L E V T Q Q P M R V G N Q V N V T C Q V R K F Y P Q S L Q L T W S E N G N V C Q R E T A S T L T E N K D G T Y N W T S W F L V N I S D Q R D D V V L T C Q V K H D G Q L A V S K R L A L E V T V H Q K D Q S S D A T P G P A S
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
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Target data
Function
Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation.
Alternative names
CD172g, SIRPB2, SIRPG, Signal-regulatory protein gamma, SIRP-gamma, CD172 antigen-like family member B, Signal-regulatory protein beta-2, SIRP-b2, SIRP-beta-2
Recommended products
Recombinant Human CD172 gamma protein is a Human Fragment protein, in the 29 to 364 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
Key facts
- Purity
- >95% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- Tag free
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- Q9P1W8-1
- Animal free
- No
- Species
- Human
- Reconstitution
- Reconstitute with sterile deionized water to a concentration of 200 µg/ml.
- Concentration
- Storage buffer
pH: 7.4
Constituents: 5% Trehalose, 0.75% Glycine, 0.61% Tris
Sequence info
Amino acid sequence
- E E E L Q M I Q P E K L L L V T V G K T A T L H C T V T S L L P V G P V L W F R G V G P G R E L I Y N Q K E G H F P R V T T V S D L T K R N N M D F S I R I S S I T P A D V G T Y Y C V K F R K G S P E N V E F K S G P G T E M A L G A K P S A P V V L G P A A R T T P E H T V S F T C E S H G F S P R D I T L K W F K N G N E L S D F Q T N V D P T G Q S V A Y S I R S T A R V V L D P W D V R S Q V I C E V A H V T L Q G D P L R G T A N L S E A I R V P P T L E V T Q Q P M R V G N Q V N V T C Q V R K F Y P Q S L Q L T W S E N G N V C Q R E T A S T L T E N K D G T Y N W T S W F L V N I S D Q R D D V V L T C Q V K H D G Q L A V S K R L A L E V T V H Q K D Q S S D A T P G P A S
- Accession
- Q9P1W8
- Protein length
- Fragment
- Predicted molecular weight
- 63.7 kDa
- Amino acids
- 29 to 364
- Nature
- Recombinant
Specifications
- Form
- Lyophilized
General info
- Function
Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -80°C
- Storage information
- Avoid freeze / thaw cycle, For long term storage it is recommended to add a carrier protein on reconstitution (0.1% HSA or BSA)
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
CD172 gamma also known as SIRP gamma or signal-regulatory protein gamma is part of the signal-regulatory protein family. This protein has a molecular mass of approximately 44 kDa. CD172 gamma is a transmembrane protein expressed mainly on the surface of immune cells including T lymphocytes and to a lesser extent on other specific blood cells. It acts through its extracellular Ig-like domains which enable it to participate in cell-cell interactions.
- Biological function summary
CD172 gamma plays a role in immune response modulation. It functions as a part of a receptor complex that assists in cell signaling and communication. This involvement includes facilitating interactions between immune cells and presenting antigens which can impact cell activation and response. CD172 gamma has specific interactions that contribute to the regulation of the immune system further enhancing its role in defining cellular activity.
- Pathways
CD172 gamma engages in immune signaling pathways. This protein is notably associated with the antigen presentation pathway where it plays a significant role in adaptive immune response. It works in conjunction with other proteins like SIRP alpha and SIRP beta forming a network that modulates immune cell signaling and activity. It influences the pathway interactions that determine how immune cells respond to various stimuli.
- Associated diseases and disorders
CD172 gamma has connections to immune-related conditions. In particular this protein has been studied in the context of autoimmune diseases where its role in immune signaling can affect disease progression. It is also linked to certain hematological disorders influencing the behavior of blood cells. CD172 gamma interacts with proteins like CD47 in these disease processes playing a distinct role in the modulation and potential progression of these conditions.
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1 product image
SDS-PAGE - Recombinant Human CD172 gamma protein (ab191638)
SDS-PAGE analysis of reduced ab191638 stained overnight with Coomassie Blue. DTT-reduced protein migrates as 68-75 kDa due to glycosylation.
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