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AB172854

Recombinant Human CD172 gamma protein (Fc Chimera)

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Recombinant Human CD172 gamma protein (Fc Chimera) is a Human Fragment protein, in the 28 to 360 aa range, expressed in HEK 293 cells, with >95%, 1 EU/µg endotoxin level, suitable for SDS-PAGE, HPLC.

View Alternative Names

CD172g, SIRPB2, SIRPG, Signal-regulatory protein gamma, SIRP-gamma, CD172 antigen-like family member B, Signal-regulatory protein beta-2, SIRP-b2, SIRP-beta-2

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

1 EU/µg

Expression system

HEK 293 cells

Tags

Tag free

Applications

SDS-PAGE, HPLC

applications

Biologically active

No

Accession

Q9P1W8

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: PBS

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "HPLC": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"GEEELQMIQPEKLLLVTVGKTATLHCTVTSLLPVGPVLWFRGVGPGRELIYNQKEGHFPRVTTVSDLTKRNNMDFSIRISSITPADVGTYYCVKFRKGSPENVEFKSGPGTEMALGAKPSAPVVLGPAARTTPEHTVSFTCESHGFSPRDITLKWFKNGNELSDFQTNVDPTGQSVAYSIRSTARVVLDPWDVRSQVICEVAHVTLQGDPLRGTANLSEAIRVPPTLEVTQQPMRVGNQVNVTCQVRKFYPQSLQLTWSENGNVCQRETASTLTENKDGTYNWTSWFLVNISDQRDDVVLTCQVKHDGQLAVSKRLALEVTVHQKDQSSDATPVDDIEGRMDEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK","proteinLength":"Fragment","predictedMolecularWeight":"64 kDa","actualMolecularWeight":null,"aminoAcidEnd":360,"aminoAcidStart":28,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q9P1W8","tags":[]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD172 gamma also known as SIRP gamma or signal-regulatory protein gamma is part of the signal-regulatory protein family. This protein has a molecular mass of approximately 44 kDa. CD172 gamma is a transmembrane protein expressed mainly on the surface of immune cells including T lymphocytes and to a lesser extent on other specific blood cells. It acts through its extracellular Ig-like domains which enable it to participate in cell-cell interactions.
Biological function summary

CD172 gamma plays a role in immune response modulation. It functions as a part of a receptor complex that assists in cell signaling and communication. This involvement includes facilitating interactions between immune cells and presenting antigens which can impact cell activation and response. CD172 gamma has specific interactions that contribute to the regulation of the immune system further enhancing its role in defining cellular activity.

Pathways

CD172 gamma engages in immune signaling pathways. This protein is notably associated with the antigen presentation pathway where it plays a significant role in adaptive immune response. It works in conjunction with other proteins like SIRP alpha and SIRP beta forming a network that modulates immune cell signaling and activity. It influences the pathway interactions that determine how immune cells respond to various stimuli.

CD172 gamma has connections to immune-related conditions. In particular this protein has been studied in the context of autoimmune diseases where its role in immune signaling can affect disease progression. It is also linked to certain hematological disorders influencing the behavior of blood cells. CD172 gamma interacts with proteins like CD47 in these disease processes playing a distinct role in the modulation and potential progression of these conditions.
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Specifications

Form

Liquid

Additional notes

Purity greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. ab172854 is 0.2 µM filtered.

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General info

Function

Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation.

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Product protocols

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Target data

Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation.
See full target information SIRPG
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