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AB177643

Recombinant Human CD1E protein (denatured)

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Recombinant Human CD1E protein (denatured) is a Human Fragment protein, in the 30 to 305 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

View Alternative Names

CD1e, hCD1e, R2G1, CD1E

1 Images
SDS-PAGE - Recombinant Human CD1E protein (denatured) (AB177643)
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Supplier Data

SDS-PAGE - Recombinant Human CD1E protein (denatured) (AB177643)

15% SDS-PAGE analysis of ab177643 (3ug)

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P15812

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris-HCl buffer

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSEEQLSFRMLQTSSFANHSWAHSEGSGWLGDLQTHGWDTVLGTIRFLKPWSHGNFSKQELKNLQSLFQLYFHSFIQIVQASAGQFQLEYPFEIQILAGCRMNAPQIFLNMAYQGSDFLSFQGISWEPSPGAGIRAQNICKVLNRYLDIKEILQSLLGHTCPRFLAGLMEAGESELKRKVKPEAWLSCGPSPGPGRLQLVCHVSGFYPKPVWVMWMRGEQEQRGTQRGDVLPNADETWYLRATLDVAAGEAAGLSCRVKHSSLGGHDLIIHWGGYS","proteinLength":"Fragment","predictedMolecularWeight":"33.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":305,"aminoAcidStart":30,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P15812","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD1E also known as CD1e is a member of the CD1 family of glycoproteins. It has a molecular mass of approximately 37 kDa. CD1E is expressed mainly in the endosomes of antigen-presenting cells such as dendritic cells and macrophages. It plays an essential role in lipid antigen processing inside the cells. By facilitating the presentation of lipid antigens to T cells CD1E helps modulate immune responses.
Biological function summary

CD1E functions as part of a larger protein complex involved in the immune system. In its role it assists in the sorting and processing of lipid antigens derived from various pathogens and endogenous sources. This activity promotes the presentation of these antigens on the cell surface enabling them to be recognized by CD1-restricted T cells. Such interactions are important for developing adaptive immune responses.

Pathways

CD1E participates in antigen processing and presentation pathways which are necessary for immune surveillance. It works closely with other CD1 family members like CD1a and CD1b to ensure the diverse display of lipid antigens to T cells. This collaboration is critical for initiating T cell-mediated immune responses against lipid-based antigens bridging innate and adaptive immunity.

CD1E has been linked to the progression and pathogenesis of certain autoimmune diseases like multiple sclerosis and rheumatoid arthritis. Dysfunction in the CD1E-mediated antigen processing pathway may lead to improper immune activation and self-reactivity. Additionally CD1E is associated with infectious diseases such as tuberculosis where it could interact with Mycobacterium tuberculosis lipids. Proteins like CD1b can influence CD1E function during these disease processes impacting the overall balance of immune responses.
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Specifications

Form

Liquid

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General info

Function

T-cell surface glycoprotein CD1e, soluble binds diacetylated lipids, including phosphatidyl inositides and diacylated sulfoglycolipids, and is required for the presentation of glycolipid antigens on the cell surface. The membrane-associated form is not active.

Post-translational modifications

Mono-ubiquitinated.. Proteolytically cleaved in late endosomes to yield a soluble form.

Subcellular localisation

Early endosome

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Product protocols

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Target data

T-cell surface glycoprotein CD1e, soluble binds diacetylated lipids, including phosphatidyl inositides and diacylated sulfoglycolipids, and is required for the presentation of glycolipid antigens on the cell surface. The membrane-associated form is not active.
See full target information CD1E
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