Recombinant Human CD27 protein
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(2 Publications)
Recombinant Human CD27 protein is a Human Full Length protein, in the 1 to 260 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.
View Alternative Names
CD27, TNFRSF7, CD27 antigen, CD27L receptor, T-cell activation antigen CD27, T14, Tumor necrosis factor receptor superfamily member 7
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human CD27 protein (AB114342)
ab114342 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
One finds CD27 at the heart of cellular immune responses. It does not function alone; instead it typically forms part of a receptor-ligand complex with CD70 which influences T cell and B cell activities. This interaction promotes cell survival and plays a role in the activation of NF-kB and MAPK8/JNK signaling pathways which are essential for immune response regulation. These pathways ensure that the body's immune cells can efficiently respond to pathogens.
Pathways
CD27 actively integrates into the NF-kB and mTOR signaling pathways which are important for regulating immune and inflammatory responses. Through these pathways CD27 works closely with proteins like TRAF2 and TRAF3 which are adapter molecules that transmit signals from the receptor. These signaling pathways provide a framework for understanding how CD27 and associated proteins work together to control immune cell behavior facilitating coordinated immune defense mechanisms.
Specifications
Form
Solid
General info
Function
Costimulatory immune-checkpoint receptor expressed at the surface of T-cells, NK-cells and B-cells which binds to and is activated by its ligand CD70/CD27L expressed by B-cells (PubMed : 28011863). The CD70-CD27 signaling pathway mediates antigen-specific T-cell activation and expansion which in turn provides immune surveillance of B-cells (PubMed : 28011863). Mechanistically, CD70 ligation activates the TRAF2-PTPN6 axis that subsequently inhibits LCK phosphorylation to promote phenotypic and transcriptional adaptations of T-cell memory (PubMed : 38354704). In addition, activation by CD70 on early progenitor cells provides a negative feedback signal to leukocyte differentiation during immune activation and thus modulates hematopoiesis (By similarity). Negatively regulates the function of Th2 lymphocytes in the adipose tissue (By similarity).
Post-translational modifications
Phosphorylated.. N-glycosylated.. O-glycosylated with core 1 or possibly core 8 glycans.
Target data
Publications (2)
Recent publications for all applications. Explore the full list and refine your search
BMC cancer 24:352 PubMed38504180
2024
Applications
Unspecified application
Species
Unspecified reactive species
Cellular & molecular immunology 16:652-665 PubMed30635649
2019
Applications
Unspecified application
Species
Unspecified reactive species
Alternative Products
Complementary Products
Primary Antibodies
AB131254
20ul selling size|RabMAb|Recombinant|KO Validated
![Flow Cytometry (Intracellular) - Anti-CD27 antibody [EPR8569] (AB131254)](https://content.abcam.com/products/images/cd27-antibody-epr8569-ab131254--flow-cytometry-intracellular-img116309.jpg)
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Product promise
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