Recombinant Human CD276 Protein
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Recombinant Human CD276 Protein is a Human Fragment protein, in the 29 to 245 aa range, expressed in HEK 293 cells, with >95%, <0.005 EU/µg endotoxin level, suitable for HPLC, SDS-PAGE, Mass Spec.
View Alternative Names
CD276, B7H3, PSEC0249, UNQ309/PRO352, CD276 antigen, 4Ig-B7-H3, B7 homolog 3, Costimulatory molecule, B7-H3
- Mass Spec
Supplier Data
Mass Spectrometry - Recombinant Human CD276 Protein (AB307810)
Mass determination by ESI-TOF. Predicted MW is 23351.36 Da (+/- 10 Da by ESI-TOF). Observed MW is 23368.18 Da.
- HPLC
Supplier Data
HPLC - Recombinant Human CD276 Protein (AB307810)
HPLC analysis of ab307810
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human CD276 Protein (AB307810)
SDS-PAGE analysis of ab307810
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
CD276 modulates immune responses by acting as a co-inhibitory ligand impacting T-cell proliferation and cytokine synthesis. Not part of a known complex it plays a role in the adaptive immune system by providing negative feedback regulation that can inhibit the immune response. This capability has implications in preventing autoimmunity but may also contribute to tumor immune evasion by reducing effective anti-tumor responses. The B7-H3/CD276 interaction with receptors such as IL receptor family members suggests its diverse immunomodulatory functions.
Pathways
CD276 participates in the T-cell receptor (TCR) signaling pathways influencing immune checkpoint pathways. It interacts with other immune checkpoint proteins like PD-L1 and CTLA-4 but its exact receptor partner remains unidentified. The presence of CD276 in these pathways highlights its role in controlling T-cell activation and tolerance. By modulating TCR signals and impacting downstream effects CD276 serves as a regulatory point that can balance immune activation and inhibition critical in immune-mediated conditions.
Specifications
Form
Lyophilized
Additional notes
SDS-PAGE >= 95%
General info
Function
May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.
Sequence similarities
Belongs to the immunoglobulin superfamily. BTN/MOG family.
Target data
Complementary Products
Primary Antibodies
AB134161
Anti-CD276 antibody [EPNCIR122]
RabMAb|Recombinant|KO Validated|20ul selling size
![Western blot - Anti-CD276 antibody [EPNCIR122] (AB134161)](https://content.abcam.com/products/images/cd276-antibody-epncir122-ab134161--western-blot-img155687.jpg)
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Product promise
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