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Recombinant human CD276 protein (Fc Chimera Active) is a Human Fragment protein, in the 27 to 461 aa range, expressed in HEK 293, with >=98% purity, < 5 EU/mg endotoxin level and suitable for SDS-PAGE, FuncS.
Alternative names=CD276 antigen, 4Ig-B7-H3, B7 homolog 3, Costimulatory molecule, B7-H3, CD276, B7H3, PSEC0249, UNQ309/PRO352
>=98% SDS-PAGE
< 5 EU/mg
HEK 293 cells
Tag free
SDS-PAGE, FuncS
Yes
G A L E V Q V P E D P V V A L V G T D A T L C C S F S P E P G F S L A Q L N L I W Q L T D T K Q L V H S F A E G Q D Q G S A Y A N R T A L F P D L L A Q G N A S L R L Q R V R V A D E G S F T C F V S I R D F G S A A V S L Q V A A P Y S K P S M T L E P N K D L R P G D T V T I T C S S Y Q G Y P E A E V F W Q D G Q G V P L T G N V T T S Q M A N E Q G L F D V H S I L R V V L G A N G T Y S C L V R N P V L Q Q D A H S S V T I T P Q R S P T G A V E V Q V P E D P V V A L V G T D A T L R C S F S P E P G F S L A Q L N L I W Q L T D T K Q L V H S F T E G R D Q G S A Y A N R T A L F P D L L A Q G N A S L R L Q R V R V A D E G S F T C F V S I R D F G S A A V S L Q V A A P Y S K P S M T L E P N K D L R P G D T V T I T C S S Y R G Y P E A E V F W Q D G Q G V P L T G N V T T S Q M A N E Q G L F D V H S V L R V V L G A N G T Y S C L V R N P V L Q Q D A H G S V T I T G Q P M T
Application | Reactivity | Dilution info | Notes |
---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application FuncS | Reactivity Reacts | Dilution info - | Notes - |
Recombinant human CD276 protein (Fc Chimera Active) is a Human Fragment protein, in the 27 to 461 aa range, expressed in HEK 293, with >=98% purity, < 5 EU/mg endotoxin level and suitable for SDS-PAGE, FuncS.
Alternative names=CD276 antigen, 4Ig-B7-H3, B7 homolog 3, Costimulatory molecule, B7-H3, CD276, B7H3, PSEC0249, UNQ309/PRO352
>=98% SDS-PAGE
< 5 EU/mg
HEK 293 cells
Tag free
SDS-PAGE, FuncS
Yes
Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated human T cells.
100 kDa
27 to 461
G A L E V Q V P E D P V V A L V G T D A T L C C S F S P E P G F S L A Q L N L I W Q L T D T K Q L V H S F A E G Q D Q G S A Y A N R T A L F P D L L A Q G N A S L R L Q R V R V A D E G S F T C F V S I R D F G S A A V S L Q V A A P Y S K P S M T L E P N K D L R P G D T V T I T C S S Y Q G Y P E A E V F W Q D G Q G V P L T G N V T T S Q M A N E Q G L F D V H S I L R V V L G A N G T Y S C L V R N P V L Q Q D A H S S V T I T P Q R S P T G A V E V Q V P E D P V V A L V G T D A T L R C S F S P E P G F S L A Q L N L I W Q L T D T K Q L V H S F T E G R D Q G S A Y A N R T A L F P D L L A Q G N A S L R L Q R V R V A D E G S F T C F V S I R D F G S A A V S L Q V A A P Y S K P S M T L E P N K D L R P G D T V T I T C S S Y R G Y P E A E V F W Q D G Q G V P L T G N V T T S Q M A N E Q G L F D V H S V L R V V L G A N G T Y S C L V R N P V L Q Q D A H G S V T I T G Q P M T
Fragment
No
Recombinant
Human
Reconstitute 100µg vial with 100 µl sterile water to a concentration of 1mg/ml. Add 1X PBS to the desired protein concentration. Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Constituents: 100% PBS
Lyophilized
May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.
Belongs to the immunoglobulin superfamily. BTN/MOG family.
Blue Ice
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
This product is an active protein and may elicit a biological response in vivo, handle with caution.
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