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Recombinant human CD276 protein (Fc Chimera Active) is a Human Fragment protein, in the 27 to 461 aa range, expressed in HEK 293, with >=98% purity, < 5 EU/mg endotoxin level and suitable for SDS-PAGE, FuncS.

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Purity

>=98% SDS-PAGE

Endotoxin level

< 5 EU/mg

Expression system

HEK 293 cells

Tags

Tag free

Applications

SDS-PAGE, FuncS

Biologically active

Yes

Sequence

G A L E V Q V P E D P V V A L V G T D A T L C C S F S P E P G F S L A Q L N L I W Q L T D T K Q L V H S F A E G Q D Q G S A Y A N R T A L F P D L L A Q G N A S L R L Q R V R V A D E G S F T C F V S I R D F G S A A V S L Q V A A P Y S K P S M T L E P N K D L R P G D T V T I T C S S Y Q G Y P E A E V F W Q D G Q G V P L T G N V T T S Q M A N E Q G L F D V H S I L R V V L G A N G T Y S C L V R N P V L Q Q D A H S S V T I T P Q R S P T G A V E V Q V P E D P V V A L V G T D A T L R C S F S P E P G F S L A Q L N L I W Q L T D T K Q L V H S F T E G R D Q G S A Y A N R T A L F P D L L A Q G N A S L R L Q R V R V A D E G S F T C F V S I R D F G S A A V S L Q V A A P Y S K P S M T L E P N K D L R P G D T V T I T C S S Y R G Y P E A E V F W Q D G Q G V P L T G N V T T S Q M A N E Q G L F D V H S V L R V V L G A N G T Y S C L V R N P V L Q Q D A H G S V T I T G Q P M T

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Shipping To:
United States

Reactivity data

Application
SDS-PAGE
Reactivity
Reacts
Dilution info
-
Notes

-

Application
FuncS
Reactivity
Reacts
Dilution info
-
Notes

-

Target data

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Recombinant human CD276 protein (Fc Chimera Active) is a Human Fragment protein, in the 27 to 461 aa range, expressed in HEK 293, with >=98% purity, < 5 EU/mg endotoxin level and suitable for SDS-PAGE, FuncS.

Key facts

Purity

>=98% SDS-PAGE

Endotoxin level

< 5 EU/mg

Expression system

HEK 293 cells

Applications

SDS-PAGE, FuncS

Biological activity

Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated human T cells.

Predicted molecular weight

100 kDa

Amino acids

27 to 461

Sequence

G A L E V Q V P E D P V V A L V G T D A T L C C S F S P E P G F S L A Q L N L I W Q L T D T K Q L V H S F A E G Q D Q G S A Y A N R T A L F P D L L A Q G N A S L R L Q R V R V A D E G S F T C F V S I R D F G S A A V S L Q V A A P Y S K P S M T L E P N K D L R P G D T V T I T C S S Y Q G Y P E A E V F W Q D G Q G V P L T G N V T T S Q M A N E Q G L F D V H S I L R V V L G A N G T Y S C L V R N P V L Q Q D A H S S V T I T P Q R S P T G A V E V Q V P E D P V V A L V G T D A T L R C S F S P E P G F S L A Q L N L I W Q L T D T K Q L V H S F T E G R D Q G S A Y A N R T A L F P D L L A Q G N A S L R L Q R V R V A D E G S F T C F V S I R D F G S A A V S L Q V A A P Y S K P S M T L E P N K D L R P G D T V T I T C S S Y R G Y P E A E V F W Q D G Q G V P L T G N V T T S Q M A N E Q G L F D V H S V L R V V L G A N G T Y S C L V R N P V L Q Q D A H G S V T I T G Q P M T

Accession
Q5ZPR3-1
Protein length

Fragment

Animal free

No

Nature

Recombinant

Species

Human

Reconstitution

Reconstitute 100µg vial with 100 µl sterile water to a concentration of 1mg/ml. Add 1X PBS to the desired protein concentration. Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

Concentration
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Storage buffer

Constituents: 100% PBS

Specifications

Form

Lyophilized

General info

Function

May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.

Sequence similarities

Belongs to the immunoglobulin superfamily. BTN/MOG family.

Storage

Shipped at conditions

Blue Ice

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

This product is an active protein and may elicit a biological response in vivo, handle with caution.

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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