Recombinant Human CD5 protein (denatured) (His tag N-Terminus)
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Recombinant Human CD5 protein (denatured) (His tag N-Terminus) is a Human Fragment protein, in the 25 to 372 aa range, expressed in Escherichia coli, with >80%, suitable for SDS-PAGE.
View Alternative Names
CD5, LEU1, T-cell surface glycoprotein CD5, Lymphocyte antigen T1/Leu-1
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human CD5 protein (denatured) (His tag N-Terminus) (AB180322)
15% SDS-PAGE analysis of ab180322 (3μg)
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
CD5 is essential in the immune system's ability to maintain tolerance to self-antigens thereby preventing autoimmune responses. CD5 forms part of a receptor complex on the cell surface that interacts with ligands and other receptors to fine-tune immune cell signaling. Its localization and function in T cells relate closely to its ability to modulate signaling pathways essential for cell survival and proliferation. This modulation is important for ensuring that immune responses are appropriate to the stimuli encountered.
Pathways
CD5 is involved in signal transduction processes important for immune tolerance and modulation. It intersects with pathways like the T cell receptor (TCR) signaling pathway and the NF-kB signaling pathway. These pathways involve interaction with proteins like Zap70 a tyrosine kinase related to TCR signaling and the downstream activation of transcription factors that regulate immune responses. The protein CRIS1 also appears in some pathway interactions highlighting the interconnected nature of immune regulatory proteins.
Specifications
Form
Liquid
General info
Function
Lymphoid-specific receptor expressed by all T-cells and in a subset of B-cells known as B1a cells. Plays a role in the regulation of TCR and BCR signaling, thymocyte selection, T-cell effector differentiation and immune tolerance. Acts by interacting with several ligands expressed on B-cells such as CD5L or CD72 and thereby plays an important role in contact-mediated, T-dependent B-cell activation and in the maintenance of regulatory T and B-cell homeostasis. Functions as a negative regulator of TCR signaling during thymocyte development by associating with several signaling proteins including LCK, CD3Z chain, PI3K or CBL (PubMed : 1384049, PubMed : 1385158). Mechanistically, co-engagement of CD3 with CD5 enhances phosphorylated CBL recruitment leading to increased VAV1 phosphorylation and degradation (PubMed : 23376399). Modulates B-cell biology through ERK1/2 activation in a Ca(2+)-dependent pathway via the non-selective Ca(2+) channel TRPC1, leading to IL-10 production (PubMed : 27499044).
Post-translational modifications
Phosphorylated on serine, threonine and tyrosine residues following TCR stimulation (PubMed:1385158). Phosphorylated by LCK on Tyr-453 and Tyr-487 upon TCR engagement.
Target data
Complementary Products
Product promise
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