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AB229360

Recombinant Human CD52 protein (Fc Chimera His Tag)

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Recombinant Human CD52 protein (Fc Chimera His Tag) is a Human Full Length protein, in the 25 to 36 aa range, expressed in Baculovirus infected insect cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

CD52, CDW52, HE5, CAMPATH-1 antigen, CDw52, Cambridge pathology 1 antigen, Epididymal secretory protein E5, Human epididymis-specific protein 5, He5

1 Images
SDS-PAGE - Recombinant Human CD52 protein (Fc Chimera His Tag) (AB229360)
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Supplier Data

SDS-PAGE - Recombinant Human CD52 protein (Fc Chimera His Tag) (AB229360)

15% SDS-PAGE analysis of 3 μg ab229360.

MW 28-40 kDa (SDS-PAGE under reducing conditions).

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

Baculovirus infected insect cells

Tags

Fc tag C-Terminus His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P31358

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: PBS, 10% Glycerol (glycerin, glycerine)

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"GQNDTSQTSSPSLEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKHHHHHH","proteinLength":"Full Length","predictedMolecularWeight":"28.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":36,"aminoAcidStart":25,"nature":"Recombinant","expressionSystem":"Baculovirus infected insect cells","accessionNumber":"P31358","tags":[{"tag":"Fc","terminus":"C-Terminus"},{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD52 also known as Campath-1 antigen is a glycoprotein that weighs approximately 12 kDa. It is mainly expressed on the surface of lymphocytes monocytes macrophages and some epithelial cells. This protein is also present on T and B cells making it a reliable marker for these immune cells. CD52's role is primarily in cell adhesion and signaling. The anti-CD52 antibody alemtuzumab targets this antigen specifically indicating its utility in clinical applications.
Biological function summary

CD52 plays an essential role in immune response regulation. It is not part of a larger protein complex but interacts dynamically with cell membranes to mediate immune cell activity. By acting as a co-stimulatory molecule for T cells CD52 influences lymphocyte activation and proliferation. This activity becomes significant in modulating immune responses showcasing its importance in immunological pathways.

Pathways

CD52 heavily influences T cell receptor signaling and cytokine production pathways. It interacts with proteins in these pathways to facilitate effective immune surveillance and response. CD52's engagement in these pathways highlights its collaboration with proteins such as CD3 and CD28 which assist in T cell activation and adaptive immunity. Such interactions highlight CD52's role in maintaining immune homeostasis.

CD52 has substantial relevance in autoimmune diseases and hematological cancers. Multiple sclerosis is one such autoimmune disorder where aberrant CD52 activity affects disease progression. Alemtuzumab an anti-CD52 monoclonal antibody is often used in treatment emphasizing CD52's clinical significance. In hematological malignancies like chronic lymphocytic leukemia CD52 facilitates abnormal lymphocyte survival and proliferation. CD52's interplay with other cell surface proteins such as CD19 further delineates its role in disease pathology and targeting strategies.
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Specifications

Form

Liquid

Additional notes

Affinity purified

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General info

Function

May play a role in carrying and orienting carbohydrate, as well as having a more specific role.

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Product protocols

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Target data

May play a role in carrying and orienting carbohydrate, as well as having a more specific role.
See full target information CD52
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