Recombinant Human CD62L protein is a Human Full Length protein, in the 1 to 375 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
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Key facts
- Expression system
- Wheat germ
- Tags
- Tag free
- Applications
- SDS-PAGE, ELISA, WB
- Biologically active
- No
Amino acid sequence
M G C R R T R E G P S K A M I F P W K C Q S T Q R D L W N I F K L W G W T M L C C D F L A H H G T D C W T Y H Y S E K P M N W Q R A R R F C R D N Y T D L V A I Q N K A E I E Y L E K T L P F S R S Y Y W I G I R K I G G I W T W V G T N K S L T E E A E N W G D G E P N N K K N K E D C V E I Y I K R N K D A G K W N D D A C H K L K A A L C Y T A S C Q P W S C S G H G E C V E I I N N Y T C N C D V G Y Y G P Q C Q F V I Q C E P L E A P E L G T M D C T H P L G N F S F S S Q C A F S C S E G T N L T G I E E T T C G P F G N W S S P E P T C Q V I Q C E P L S A P D L G I M N C S H P L A S F S F T S A C T F I C S E G T E L I G K K K T I C E S S G I W S N P S P I C Q K L D K S F S M I K E G D Y N P L F I P V A V M V T A F S G L A F I I W L A R R L K K G M
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
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Target data
Function
Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells (PubMed:12403782, PubMed:28011641, PubMed:28489325). Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia (PubMed:12403782, PubMed:28011641).
Alternative names
CD62L, LNHR, LYAM1, SELL, L-selectin, CD62 antigen-like family member L, Leukocyte adhesion molecule 1, Leukocyte surface antigen Leu-8, Leukocyte-endothelial cell adhesion molecule 1, Lymph node homing receptor, TQ1, gp90-MEL, LAM-1, LECAM1
Recommended products
Recombinant Human CD62L protein is a Human Full Length protein, in the 1 to 375 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- Tag free
- Applications
- SDS-PAGE, ELISA, WB
- Biologically active
- No
- Accession
- P14151-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- M G C R R T R E G P S K A M I F P W K C Q S T Q R D L W N I F K L W G W T M L C C D F L A H H G T D C W T Y H Y S E K P M N W Q R A R R F C R D N Y T D L V A I Q N K A E I E Y L E K T L P F S R S Y Y W I G I R K I G G I W T W V G T N K S L T E E A E N W G D G E P N N K K N K E D C V E I Y I K R N K D A G K W N D D A C H K L K A A L C Y T A S C Q P W S C S G H G E C V E I I N N Y T C N C D V G Y Y G P Q C Q F V I Q C E P L E A P E L G T M D C T H P L G N F S F S S Q C A F S C S E G T N L T G I E E T T C G P F G N W S S P E P T C Q V I Q C E P L S A P D L G I M N C S H P L A S F S F T S A C T F I C S E G T E L I G K K K T I C E S S G I W S N P S P I C Q K L D K S F S M I K E G D Y N P L F I P V A V M V T A F S G L A F I I W L A R R L K K G M
- Accession
- P14151
- Protein length
- Full Length
- Predicted molecular weight
- 66.99 kDa
- Amino acids
- 1 to 375
- Nature
- Recombinant
Specifications
- Form
- Liquid
General info
- Function
Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells (PubMed:12403782, PubMed:28011641, PubMed:28489325). Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia (PubMed:12403782, PubMed:28011641).
- Sequence similarities
Belongs to the selectin/LECAM family.
- Post-translational modifications
N-glycosylated.
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
CD62L also known as L-selectin is a cell adhesion molecule with a mass of approximately 74 kDa. It is part of the L-selectin family and is found on the surface of leukocytes including T cells B cells neutrophils and monocytes. Mouse models frequently study CD62L under the name "MEL-14". CD62L plays an important role in mediating the adhesion and rolling of leukocytes on blood vessel endothelial cells during the immune response. Its structure allows it to interact specifically with carbohydrates on endothelial cells facilitating the initial steps of leukocyte extravasation into tissues.
- Biological function summary
CD62L is involved in the migration of leukocytes into lymphoid tissues and sites of inflammation. It is not known to be part of a larger protein complex; rather it functions independently on the cell membrane. CD62L also assists in the homing of naive lymphocytes to peripheral lymph nodes. The molecule regulates how immune cells enter tissues through high endothelial venules acting as a critical entry point for leukocyte trafficking.
- Pathways
CD62L contributes significantly to the immune trafficking pathway and leukocyte adhesion cascade. It works closely with other adhesion molecules like CD44 and CD54 (ICAM-1) which are important within the context of cellular responses during inflammation. CD62L's function in these pathways ensures that immune cells are properly directed to areas where they are needed most whether that is secondary lymphoid organs or inflamed tissues.
- Associated diseases and disorders
CD62L expression and function have been associated with inflammatory conditions and certain immune-related pathologies such as multiple sclerosis and rheumatoid arthritis. Altered CD62L expression can affect lymphocyte homing potentially playing a role in the pathogenesis of these conditions. The role of CD62L is also linked to proteins like CD44 which can modulate cell interactions and have overlapping functions in disease mechanisms influencing disease progression or resolution.
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1 product image
SDS-PAGE - Recombinant Human CD62L protein (ab132972)
12.5% SDS-PAGE analysis of ab132972 stained with Coomassie Blue.
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