Recombinant Human CD83 protein (Fc tag C-Terminus + Avi tag C-Terminus)
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Recombinant Human CD83 protein (Fc tag C-Terminus + Avi tag C-Terminus) is a Human Fragment protein, in the 20 to 144 aa range, expressed in HEK 293 cells, with >90%, suitable for SDS-PAGE.
View Alternative Names
CD83, CD83 antigen, hCD83, B-cell activation protein, Cell surface protein HB15
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human CD83 protein (Fc tag C-Terminus + Avi tag C-Terminus) (AB271452)
SDS-PAGE analysis of 4 μg ab271452.
Complementary Products
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The primary role of CD83 involves the regulation of immune responses. It functions by modulating the activity and communication of immune cells especially impacting the antigen-presenting capabilities of dendritic cells. CD83 also plays a role in promoting the maturation of these cells and influencing T-cell responses. Although CD83 is not generally recognized as a part of a complex its interactions with other cell surface molecules are significant for immune system function.
Pathways
CD83 has notable involvement in immune signaling pathways including the NF-kB and JAK/STAT pathways. These pathways are critical for transmitting signals that influence cell survival proliferation and activation. Through these pathways CD83 interacts with proteins such as cytokines and growth factors which further modulate their effects on immune cells and their responses.
Specifications
Form
Liquid
General info
Function
Transmembrane glycoprotein predominantly found on the surface of many immune cells including dendritic cells or lymphocytes that plays various roles in immune response regulation. Plays an essential role in CD4(+) T-selection, differentiation and stability by regulating the activity of the major E3 ubiquitin ligase responsible for controlling MHCII trafficking MARCHF8. Also inhibits MARCHF1 association with MHCII or CD86 to prevent their ubiquitination and subsequent degradation (PubMed : 21220452). In addition, acts as an important modulator of protective responses against acute infections (By similarity).
Post-translational modifications
Glycosylated when expressed on activated dendritic cells.
Target data
Product promise
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