Recombinant Human CD90 / Thy1 protein (His tag) is a Human Fragment protein, in the 1 to 130 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
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Key facts
- Purity
- >95% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M N L A I S I A L L L T V L Q V S R G Q K V T S L T A C L V D Q S L R L D C R H E N T S S S P I Q Y E F S L T R E T K K H V L F G T V G V P E H T Y R S R T N F T S K Y N M K V L Y L S A F T S K D E G T Y T C A L H H S G H S P P I S S Q N V T V L R D K L V K C
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.
Alternative names
CD90, Thy-1 membrane glycoprotein, CDw90, Thy-1 antigen, THY1
Recommended products
Recombinant Human CD90 / Thy1 protein (His tag) is a Human Fragment protein, in the 1 to 130 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
Key facts
- Purity
- >95% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- P04216-1
- Animal free
- No
- Carrier free
- Yes
- Species
- Human
- Concentration
- Storage buffer
pH: 7.4
Constituents: 100% PBS
Sequence info
Amino acid sequence
- M N L A I S I A L L L T V L Q V S R G Q K V T S L T A C L V D Q S L R L D C R H E N T S S S P I Q Y E F S L T R E T K K H V L F G T V G V P E H T Y R S R T N F T S K Y N M K V L Y L S A F T S K D E G T Y T C A L H H S G H S P P I S S Q N V T V L R D K L V K C
- Accession
- P04216
- Protein length
- Fragment
- Predicted molecular weight
- 14 kDa
- Amino acids
- 1 to 130
- Nature
- Recombinant
- Tags
- His tag C-Terminus
Specifications
- Form
- Lyophilized
General info
- Function
May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
CD90 also known as Thy1 is a glycoprotein with a molecular mass of approximately 25-37 kDa. It is highly conserved across species and found on the surface of various cell types including fibroblasts neurons and endothelial cells. CD90 is expressed in these cells in tissues such as the brain thymus and lungs. Researchers use anti-CD90 antibodies for detection often in combination with CD90 FITC in immunofluorescence assays. CD90 serves as a useful cell marker particularly in identifying mesenchymal stem cells (MSCs).
- Biological function summary
CD90 plays a role in cell-cell and cell-matrix interactions contributing to cellular adhesion migration and signal transduction. It functions as part of a complex involving integrins which mediate its interaction with the extracellular matrix. This protein also influences T-cell activation reflecting its importance in immune response regulation. Its presence aids in modulating response to injury and promoting tissue repair due to its association with stem and progenitor cells.
- Pathways
CD90 engagement affects focal adhesion and MAPK signaling pathways. It interacts with integrins like αvβ3 and α5β1 influencing cell movement and proliferation processes. CD90 involvement in these pathways allows it to regulate responses important for cell survival and communication within various tissues. These interactions highlight the protein's role in maintaining cellular homeostasis and regulating physiological processes.
- Associated diseases and disorders
CD90 has associations with fibrosis and cancer. In fibrotic conditions CD90 expression affects fibroblast activity influencing tissue scarring in organs such as the liver and lungs. In cancer CD90 modifies tumor progression and metastasis by impacting cell adhesion and migration with connections to proteins like TGF-beta which further drive these processes. Understanding CD90 in disease contexts facilitates the development of therapeutic strategies aimed at modulating its activity.
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1 product image
SDS-PAGE - Recombinant Human CD90 / Thy1 protein (His tag) (ab276727)
SDS-PAGE analysis of ab276727
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