Recombinant Human CD93 protein (His tag) is a Human Fragment protein, in the 1 to 580 aa range, expressed in HEK 293, with >90% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
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Key facts
- Purity
- >90% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M A T S M G L L L L L L L L L T Q P G A G T G A D T E A V V C V G T A C Y T A H S G K L S A A E A Q N H C N Q N G G N L A T V K S K E E A Q H V Q R V L A Q L L R R E A A L T A R M S K F W I G L Q R E K G K C L D P S L P L K G F S W V G G G E D T P Y S N W H K E L R N S C I S K R C V S L L L D L S Q P L L P S R L P K W S E G P C G S P G S P G S N I E G F V C K F S F K G M C R P L A L G G P G Q V T Y T T P F Q T T S S S L E A V P F A S A A N V A C G E G D K D E T Q S H Y F L C K E K A P D V F D W G S S G P L C V S P K Y G C N F N N G G C H Q D C F E G G D G S F L C G C R P G F R L L D D L V T C A S R N P C S S S P C R G G A T C V L G P H G K N Y T C R C P Q G Y Q L D S S Q L D C V D V D E C Q D S P C A Q E C V N T P G G F R C E C W V G Y E P G G P G E G A C Q D V D E C A L G R S P C A Q G C T N T D G S F H C S C E E G Y V L A G E D G T Q C Q D V D E C V G P G G P L C D S L C F N T Q G S F H C G C L P G W V L A P N G V S C T M G P V S L G P P S G P P D E E D K G E K E G S T V P R A A T A S P T R G P E G T P K A T P T T S R P S L S S D A P I T S A P L K M L A P S G S P G V W R E P S I H H A T A A S G P Q E P A G G D S S V A T Q N N D G T D G Q K
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Cell surface receptor that plays a role in various physiological processes including inflammation, phagocytosis, and cell adhesion. Plays a role in phagocytosis and enhances the uptake of apoptotic cells and immune complexes by acting as a receptor for defense collagens including surfactant protein A/SFTPA1, C1q, and mannose-binding lectin (MBL2) (PubMed:7977768). Plays a role in the regulation of endothelial cell function and adhesion by activating angiogenesis (PubMed:24809468). Mechanistically, exerts its angiogenic function by associating with beta-dystroglycan, leading to SRC-dependent phosphorylation and subsequent recruitment of CBL. In turn, CBL provides a docking site for downstream signaling components, such as CRKL to enhance cell migration (PubMed:26848865). Participates in angiogenesis also by acting as a receptor for the ECM pan-endothelial glycoprotein multimerin-2/MMRN2 and IGFBP7 ligands (PubMed:28671670, PubMed:36265539, PubMed:38218180). Both ligands play a non-redundant role in CD93-mediated endothelial cell function (PubMed:38218180). Acts as a key regulator of endothelial barrier function through modulating VEGFR2 function (By similarity).
Alternative names
CD93, C1QR1, MXRA4, Complement component C1q receptor, C1q/MBL/SPA receptor, CDw93, Complement component 1 q subcomponent receptor 1, Matrix-remodeling-associated protein 4, C1qR, C1qR(p), C1qRp
Recommended products
Recombinant Human CD93 protein (His tag) is a Human Fragment protein, in the 1 to 580 aa range, expressed in HEK 293, with >90% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
Key facts
- Purity
- >90% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- Q9NPY3-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 7.4
Constituents: 100% PBS
Sequence info
Amino acid sequence
- M A T S M G L L L L L L L L L T Q P G A G T G A D T E A V V C V G T A C Y T A H S G K L S A A E A Q N H C N Q N G G N L A T V K S K E E A Q H V Q R V L A Q L L R R E A A L T A R M S K F W I G L Q R E K G K C L D P S L P L K G F S W V G G G E D T P Y S N W H K E L R N S C I S K R C V S L L L D L S Q P L L P S R L P K W S E G P C G S P G S P G S N I E G F V C K F S F K G M C R P L A L G G P G Q V T Y T T P F Q T T S S S L E A V P F A S A A N V A C G E G D K D E T Q S H Y F L C K E K A P D V F D W G S S G P L C V S P K Y G C N F N N G G C H Q D C F E G G D G S F L C G C R P G F R L L D D L V T C A S R N P C S S S P C R G G A T C V L G P H G K N Y T C R C P Q G Y Q L D S S Q L D C V D V D E C Q D S P C A Q E C V N T P G G F R C E C W V G Y E P G G P G E G A C Q D V D E C A L G R S P C A Q G C T N T D G S F H C S C E E G Y V L A G E D G T Q C Q D V D E C V G P G G P L C D S L C F N T Q G S F H C G C L P G W V L A P N G V S C T M G P V S L G P P S G P P D E E D K G E K E G S T V P R A A T A S P T R G P E G T P K A T P T T S R P S L S S D A P I T S A P L K M L A P S G S P G V W R E P S I H H A T A A S G P Q E P A G G D S S V A T Q N N D G T D G Q K
- Accession
- Q9NPY3
- Protein length
- Fragment
- Predicted molecular weight
- 59.6 kDa
- Amino acids
- 1 to 580
- Nature
- Recombinant
- Tags
- His tag C-Terminus
Specifications
- Form
- Lyophilized
General info
- Function
Cell surface receptor that plays a role in various physiological processes including inflammation, phagocytosis, and cell adhesion. Plays a role in phagocytosis and enhances the uptake of apoptotic cells and immune complexes by acting as a receptor for defense collagens including surfactant protein A/SFTPA1, C1q, and mannose-binding lectin (MBL2) (PubMed:7977768). Plays a role in the regulation of endothelial cell function and adhesion by activating angiogenesis (PubMed:24809468). Mechanistically, exerts its angiogenic function by associating with beta-dystroglycan, leading to SRC-dependent phosphorylation and subsequent recruitment of CBL. In turn, CBL provides a docking site for downstream signaling components, such as CRKL to enhance cell migration (PubMed:26848865). Participates in angiogenesis also by acting as a receptor for the ECM pan-endothelial glycoprotein multimerin-2/MMRN2 and IGFBP7 ligands (PubMed:28671670, PubMed:36265539, PubMed:38218180). Both ligands play a non-redundant role in CD93-mediated endothelial cell function (PubMed:38218180). Acts as a key regulator of endothelial barrier function through modulating VEGFR2 function (By similarity).
- Post-translational modifications
N- and O-glycosylated.
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
CD93 also known as C1q receptor and a type I transmembrane glycoprotein weighs approximately 68 kDa. This protein is mainly expressed on platelets monocytes endothelial cells and some cell lines within the immune system. CD93 is known for engaging in cell adhesion and phagocytosis processes. It has a notable presence on the surface of circulating cells indicating its involvement in physiological interactions essential for cellular communication.
- Biological function summary
CD93 contributes to cellular processes through its role in the clearance of apoptotic cells and immune surveillance. It also partakes in angiogenesis facilitating the growth of new blood vessels. CD93 often functions as part of a larger complex in binding with other molecules to support cellular communication. By modulating the immune response CD93 ensures efficient removal of cellular debris maintaining homeostasis and preventing autoimmune reactions.
- Pathways
CD93 operates within the innate immune response and complement system pathways. It closely interacts with other proteins such as C1q which is part of the complement activation pathway. This interaction supports the clearance of immune complexes and cellular debris. By facilitating these processes CD93 aids in maintaining the balance between immune activation and tolerance.
- Associated diseases and disorders
CD93 has associations with inflammatory diseases and cancer progression. In inflammatory diseases its role in the immune system implicates it in conditions characterized by excessive inflammation often relating to the misregulation of immune functions. As for cancer CD93's involvement in angiogenesis links it to tumor growth with connections seen alongside vascular endothelial growth factor (VEGF) pathways. These insights into CD93's role suggest its potential as a therapeutic target in treating related pathological states.
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SDS-PAGE - Recombinant Human CD93 protein (His tag) (ab276485)
SDS-PAGE analysis of ab276485
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