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AB271455

Recombinant Human CD96 protein (Biotin) (Avi tag C-Terminus + Fc tag C-Terminus)

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Recombinant Human CD96 protein (Biotin) (Avi tag C-Terminus + Fc tag C-Terminus) is a Human Fragment protein, in the 22 to 519 aa range, expressed in HEK 293 cells, with >90%, suitable for SDS-PAGE.

View Alternative Names

CD96, T-cell surface protein tactile, Cell surface antigen CD96, T cell-activated increased late expression protein

1 Images
SDS-PAGE - Recombinant Human CD96 protein (Biotin) (Avi tag C-Terminus + Fc tag C-Terminus) (AB271455)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human CD96 protein (Biotin) (Avi tag C-Terminus + Fc tag C-Terminus) (AB271455)

SDS-PAGE analysis of 3 μg ab271455.

This protein runs at a higher molecular weight due to glycosylation.

Key facts

Purity

>90% SDS-PAGE

Expression system

HEK 293 cells

Tags

Avi tag C-Terminus Fc tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Conjugation

Biotin

Excitation/Emission
Accession

P40200

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: 20% Glycerol (glycerin, glycerine), 0.64% Sodium chloride, 0.13% Sodium phosphate, 0.02% Potassium chloride

storage-buffer

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Complementary Products

Primary Antibodies

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Proteins & Peptides

AB163782

Recombinant Human VISTA protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human VISTA protein (GST tag N-Terminus) (AB163782)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p>This protein runs at a higher MW by SDS-PAGE due to glycosylation.</p>" } } }
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Product details

Enzymatically biotin-labeled using Avi-tag™ technology
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Sequence info

[{"sequence":"GVWEKTVNTEENVYATLGSDVNLTCQTQTVGFFVQMQWSKVTNKIDLIAVYHPQYGFYCAYGRPCESLVTFTETPENGSKWTLHLRNMSCSVSGRYECMLVLYPEGIQTKIYNLLIQTHVTADEWNSNHTIEIEINQTLEIPCFQNSSSKISSEFTYAWSVENSSTDSWVLLSKGIKEDNGTQETLISQNHLISNSTLLKDRVKLGTDYRLHLSPVQIFDDGRKFSCHIRVGPNKILRSSTTVKVFAKPEIPVIVENNSTDVLVERRFTCLLKNVFPKANITWFIDGSFLHDEKEGIYITNEERKGKDGFLELKSVLTRVHSNKPAQSDNLTIWCMALSPVPGNKVWNISSEKITFLLGSEISSTDPPLSVTESTLDTQPSPASSVSPARYPATSSVTLVDVSALRPNTTPQPSNSSMTTRGFNYPWTSSGTDTKKSVSRIPSETYSSSPSGAGSTLHDNVFTSTARAFSEVPTTANGSTKTNHVHITGIVVNKPKDGM","proteinLength":"Fragment","predictedMolecularWeight":"84 kDa","actualMolecularWeight":null,"aminoAcidEnd":519,"aminoAcidStart":22,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"P40200","tags":[{"tag":"Avi","terminus":"C-Terminus"},{"tag":"Fc","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Storage information
Avoid freeze / thaw cycle|Store in the dark
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD96 also known as TACTILE is an immunoglobulin-like protein weighing approximately 65 kDa. This protein is expressed mostly on T cells and natural killer (NK) cells with its presence also noted on certain leukemic cells. CD96 functions mechanistically as an adhesion molecule mediating interaction between cells significantly involving in immune response modulation. Through binding proteins like CD155 it regulates immune cell migration and activity playing a significant role in cellular communication within the immune system.
Biological function summary

The CD96 protein contributes to the immune synapse formation by interacting with other cell surface and intracellular proteins. It is not directly part of a multiprotein complex but closely interacts with the receptor-ligand pairs within immune cell networks. It plays a role in the control of NK cell activity and helps maintain immune homeostasis by balancing activation and inhibition cues.

Pathways

The CD96 protein significantly impacts immunological pathways particularly those involving T cell and NK cell activation. It connects with pathways such as the DNAM-1 (CD226) and CD155 axis influencing immune cell recognition and response. These pathways regulate cellular activities like cytotoxicity and cytokine production where CD96 collaborates with proteins like DNAM-1 and TIGIT to fine-tune immune responses.

CD96 is closely associated with cancer and autoimmune diseases. Its expression level and functional role in cell adhesion and immune response modulation affect tumor immune evasion and surveillance often serving as a potential therapeutic target in cancer immunotherapy. Moreover its interactions with CD155 and DNAM-1 suggest its involvement in autoimmune conditions where regulation of immune cell activity becomes dysregulated pointing towards its relevance in diseases like rheumatoid arthritis.
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Specifications

Form

Liquid

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General info

Function

May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation.

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Product protocols

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Target data

May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation.
See full target information CD96
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Product promise

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