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AB131865

Recombinant Human CD97 protein (GST tag N-Terminus)

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Recombinant Human CD97 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 742 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

View Alternative Names

CD97, ADGRE5, Adhesion G protein-coupled receptor E5, Leukocyte antigen CD97

1 Images
SDS-PAGE - Recombinant Human CD97 protein (GST tag N-Terminus) (AB131865)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human CD97 protein (GST tag N-Terminus) (AB131865)

12.5% SDS-PAGE analysis of ab131865 stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA, SDS-PAGE

applications

Biologically active

No

Accession

P48960

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Primary Antibodies

AB108368

Anti-CD97 antibody [EPR4427]

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD97 antibody [EPR4427] (AB108368)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGGRVFLAFCVWLTLPGAETQDSRGCARWCPQNSSCVNATACRCNPGFSSFSEIITTPTETCDDINECATPSKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECSSGRHQCDSSTVCFNTVGSYSCRCRPGWKPRHGIPNNQKDTVCEDMTFSTWTPPPGVHSQTLSRFFDKVQDLGRDSKTSSAEVTIQNVIKLVDELMEAPGDVEALAPPVRHLIATQLLSNLEDIMRILAKSLPKGPFTYISPSNTELTLMIQERGDKNVTMGQSSARMKLNWAVAAGAEDPGPAVAGILSIQNMTTLLANASLNLHSKKQAELEEIYESSIRGVQLRRLSAVNSIFLSHNNTKELNSPILFAFSHLESSDGEAGRDPPAKDVMPGPRQELLCAFWKSDSDRGGHWATEGCQVLGSKNGSTTCQCSHLSSFAILMAHYDVEDWKLTLITRVGLALSLFCLLLCILTFLLVRPIQGSRTTIHLHLCICLFVGSTIFLAGIENEGGQVGLRCRLVAGLLHYCFLAAFCWMSLEGLELYFLVVRVFQGQGLSTRWLCLIGYGVPLLIVGVSAAIYSKGYGRPRYCWLDFEQGFLWSFLGPVTFIILCNAVIFVTTVWKLTQKFSEINPDMKKLKKARALTITAIAQLFLLGCTWVFGLFIFDDRSLVLTYVFTILNCLQGAFLYLLHCLLNKKVREEYRKWACLVAGGSKYSEFTSTTSGTGHNQTRALRASESGI","proteinLength":"Full Length","predictedMolecularWeight":"107.36 kDa","actualMolecularWeight":null,"aminoAcidEnd":742,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"P48960","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD97 also known as adhesion G protein-coupled receptor E5 is a member of the EGF-TM7 subfamily of adhesion GPCRs. The protein has a mass of approximately 83-93 kDa and consists of distinct extracellular transmembrane and cytoplasmic domains. CD97 expresses highly on cells of the immune system especially granulocytes activated T-lymphocytes and smooth muscle cells. Researchers frequently link CD97 expression to immune cell activation and migration processes.
Biological function summary

CD97 plays a significant role in cell communication and adhesion. The protein is part of a multiprotein complex and interacts with chondroitin sulfate and other heparan sulfate proteoglycans. This interaction modulates inflammatory responses and tissue remodeling. CD97 influences immune responses by mediating cellular interaction and signaling through its long extracellular domain. Its activity is essential for leukocyte trafficking and extravasation.

Pathways

CD97 participates in important cell adhesion and immune system pathways. It interacts notably with the EGF-like crossover domains and the GPCR pathways. Related proteins such as CD55 also known as decay-accelerating factor interact with CD97 influencing the immune regulatory processes. These interactions enhance our understanding of leukocyte recruitment and the maintenance of tissue architecture during inflammatory responses.

CD97 is associated with autoimmune diseases and cancer. High CD97 expression levels relate to diseases like rheumatoid arthritis and certain types of tumors including gastric carcinoma. In cancer CD97 interacts with integrin molecules promoting metastasis and tumor invasion. Understanding CD97's connection to integrins and other components could provide insights into therapeutic targets for autoimmune and cancer treatment.
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Specifications

Form

Liquid

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General info

Function

Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration.

Sequence similarities

Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.

Post-translational modifications

Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.

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Product protocols

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Target data

Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration.
See full target information ADGRE5
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Product promise

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