Recombinant Human CDKN2A/p16INK4a protein is a Human Full Length protein, in the 1 to 156 aa range, expressed in Escherichia coli, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE, HPLC.
>95% SDS-PAGE
< 1 EU/µg
Escherichia coli
Tag free
SDS-PAGE, HPLC
No
M E P A A G S S M E P S A D W L A T A A A R G R V E E V R A L L E A G A L P N A P N S Y G R R P I Q V M M M G S A R V A E L L L L H G A E P N C A D P A T L T R P V H D A A R E G F L D T L V V L H R A G A R L D V R D A W G R L P V D L A E E L G H R D V A R Y L R A A A G G T R G S N H A R I D A A E G P S D I P D
Application | Reactivity | Dilution info | Notes |
---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application HPLC | Reactivity Reacts | Dilution info - | Notes - |
Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.
CDKN2, MTS1, CDKN2A, Cyclin-dependent kinase inhibitor 2A, Cyclin-dependent kinase 4 inhibitor A, Multiple tumor suppressor 1, p16-INK4a, CDK4I, MTS-1, p16-INK4, p16INK4A
Recombinant Human CDKN2A/p16INK4a protein is a Human Full Length protein, in the 1 to 156 aa range, expressed in Escherichia coli, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE, HPLC.
>95% SDS-PAGE
< 1 EU/µg
Escherichia coli
Tag free
SDS-PAGE, HPLC
No
No
Human
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/m. Do not vortex. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C. Lyophilized protein is stable at room temperature for 1 month and at 4°C for 6 months. Reconstituted working aliquots are stable for 1 week at 2°C to 8°C and for 3 months at -20°C to -80°C.
Constituents: 0.58% Sodium chloride, 0.15% Sodium citrate, 0.01% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
M E P A A G S S M E P S A D W L A T A A A R G R V E E V R A L L E A G A L P N A P N S Y G R R P I Q V M M M G S A R V A E L L L L H G A E P N C A D P A T L T R P V H D A A R E G F L D T L V V L H R A G A R L D V R D A W G R L P V D L A E E L G H R D V A R Y L R A A A G G T R G S N H A R I D A A E G P S D I P D
Full Length
16.5 kDa
1 to 156
Recombinant
Lyophilized
>95% by HPLC analysis.
Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.
Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.
Phosphorylation seems to increase interaction with CDK4.
Nucleus
Blue Ice
1-2 weeks
+4°C
-20°C
Avoid freeze / thaw cycle
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