Products
Sample Prep & Detection Kits
Conjugation kitsPurification kitsSample preparation kitsChromogen kitsIHC kitsChIP kitsAccessory Reagents & Controls
Accessory reagents & controlsBiochemicals
BiochemicalsProteins and Peptides
Proteins and peptidesOur latest ELISA kit: Human Tau (phospho T217) - Intracellular
Highly sensitive kit offering the most promising biomarkers for Alzheimer’s disease diagnostics. Learn about all product ranges with our product overviews.
Resources
Featured events
Make new connections at our global events.
Support
Our programs
New Lab Program
Get a head start with our exclusive new lab discount. Enjoy 20% off and free shipping for three months.
New Biotech Program
Just starting out? Get 15% off and free shipping to your lab for six months.
Product promise
Peace of mind that all products perform as stated.
Product reviews
Leave reviews, get rewarded and help your community.
Trial program
Try untested species and applications to earn money off your next order.
Recombinant Human CDKN2A/p16INK4a protein is a Human Full Length protein, in the 1 to 156 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE.
Alternative names=Cyclin-dependent kinase inhibitor 2A, Cyclin-dependent kinase 4 inhibitor A, Multiple tumor suppressor 1, p16-INK4a, CDK4I, MTS-1, p16-INK4, p16INK4A, CDKN2A, MTS1, CDKN2
- Purity
>95% SDS-PAGE
- Expression system
Escherichia coli
- Tags
Tag free
- Applications
SDS-PAGE
- Biologically active
No
- Sequence
M E P A A G S S M E P S A D W L A T A A A R G R V E E V R A L L E A G A L P N A P N S Y G R R P I Q V M M M G S A R V A E L L L L H G A E P N C A D P A T L T R P V H D A A R E G F L D T L V V L H R A G A R L D V R D A W G R L P V D L A E E L G H R D V A R Y L R A A A G G T R G S N H A R I D A A E G P S D I P D
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Images
Recommended products
Recombinant Human CDKN2A/p16INK4a protein is a Human Full Length protein, in the 1 to 156 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE.
Alternative names=Cyclin-dependent kinase inhibitor 2A, Cyclin-dependent kinase 4 inhibitor A, Multiple tumor suppressor 1, p16-INK4a, CDK4I, MTS-1, p16-INK4, p16INK4A, CDKN2A, MTS1, CDKN2
Key facts
- Purity
>95% SDS-PAGE
- Expression system
Escherichia coli
- Tags
Tag free
- Applications
SDS-PAGE
- Biologically active
No
- Predicted molecular weight
16.5 kDa
- Amino acids
1 to 156
- Sequence
M E P A A G S S M E P S A D W L A T A A A R G R V E E V R A L L E A G A L P N A P N S Y G R R P I Q V M M M G S A R V A E L L L L H G A E P N C A D P A T L T R P V H D A A R E G F L D T L V V L H R A G A R L D V R D A W G R L P V D L A E E L G H R D V A R Y L R A A A G G T R G S N H A R I D A A E G P S D I P D
- Accession
- P42771-1
- Protein length
Full Length
- Animal free
No
- Nature
Recombinant
- Species
Human
- Reconstitution
Reconstitute with 1x PBS, pH 8.0. to a concentration of 0.1-1.0 mg/ml.
- Concentration
- Storage buffer
Constituents: 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.00268% PBS
Specifications
- Form
Lyophilized
- Additional notes
Purity is greater than 95% by SDS-PAGE gel and HPLC analyses.
General info
- Function
Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.
- Sequence similarities
Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.
- Post-translational modifications
Phosphorylation seems to increase interaction with CDK4.
- Subcellular localisation
Nucleus
Storage
- Shipped at conditions
Blue Ice
- Appropriate long-term storage conditions
-20°C
- Storage information
Stable for 12 months at -20°C
Notes
Endotoxin level is less than 0.1 ng per µg (1EU/µg).
Product promise
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com