Recombinant Human CDKN2A/p16INK4a protein is a Human Full Length protein, in the 1 to 156 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE.
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- Asian Pacific journal of cancer prevention : APJCP 16:5115-82015The p16INK4a Antibody Immobilization Method for Immonosensor Application.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLi Yang,Xian-He Huang,Liang SunPubMed 26163652
- Asian Pacific journal of cancer prevention : APJCP 15:9375-82014A piezoelectric immunosensor for early cervical cancer detection.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLi Yang,Xianhe Huang,Liang SunPubMed 25422227
Key facts
- Purity
- >95% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- Tag free
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M E P A A G S S M E P S A D W L A T A A A R G R V E E V R A L L E A G A L P N A P N S Y G R R P I Q V M M M G S A R V A E L L L L H G A E P N C A D P A T L T R P V H D A A R E G F L D T L V V L H R A G A R L D V R D A W G R L P V D L A E E L G H R D V A R Y L R A A A G G T R G S N H A R I D A A E G P S D I P D
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
The protein expressed by the gene CDKN2A acts as a negative regulator of normal cell proliferation by strongly interacting with CDK4 and CDK6. This interaction inhibits the ability of CDK4 and CDK6 to interact with cyclins D and to phosphorylate the retinoblastoma protein. This supplementary information is collated from multiple sources and compiled automatically.
Alternative names
CDKN2, MTS1, CDKN2A, Cyclin-dependent kinase inhibitor 2A, Cyclin-dependent kinase 4 inhibitor A, Multiple tumor suppressor 1, p16-INK4a, CDK4I, MTS-1, p16-INK4, p16INK4A
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Recombinant Human CDKN2A/p16INK4a protein is a Human Full Length protein, in the 1 to 156 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE.
Key facts
- Purity
- >95% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- Tag free
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- P42771-1
- Animal free
- No
- Species
- Human
- Reconstitution
- Reconstitute with 1x PBS, pH 8.0. to a concentration of 0.1-1.0 mg/ml.
- Concentration
- Storage buffer
Constituents: 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.00268% PBS
Sequence info
Amino acid sequence
- M E P A A G S S M E P S A D W L A T A A A R G R V E E V R A L L E A G A L P N A P N S Y G R R P I Q V M M M G S A R V A E L L L L H G A E P N C A D P A T L T R P V H D A A R E G F L D T L V V L H R A G A R L D V R D A W G R L P V D L A E E L G H R D V A R Y L R A A A G G T R G S N H A R I D A A E G P S D I P D
- Accession
- P42771
- Protein length
- Full Length
- Predicted molecular weight
- 16.5 kDa
- Amino acids
- 1 to 156
- Nature
- Recombinant
Specifications
- Form
- Lyophilized
- Additional notes
Purity is greater than 95% by SDS-PAGE gel and HPLC analyses.
General info
- Function
The protein expressed by the gene CDKN2A acts as a negative regulator of normal cell proliferation by strongly interacting with CDK4 and CDK6. This interaction inhibits the ability of CDK4 and CDK6 to interact with cyclins D and to phosphorylate the retinoblastoma protein.
This supplementary information is collated from multiple sources and compiled automatically.- Sequence similarities
Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.
- Post-translational modifications
Phosphorylation seems to increase interaction with CDK4.
- Subcellular localisation
- Nucleus
Storage
- Shipped at conditions
- Blue Ice
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Stable for 12 months at -20°C
Notes
Endotoxin level is less than 0.1 ng per µg (1EU/µg).
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1 product image
Sandwich ELISA - Recombinant Human CDKN2A/p16INK4a protein (ab84075)
Standard Curve for CDKN2A/p16INK4a (Analyte: CDKN2A/p16INK4a protein (Human) (ab84075)); dilution
range 1pg/ml to 1μg/ml using Capture Antibody Mouse monoclonal [DCS50.1] to CDKN2A/p16INK4a
(Anti-CDKN2A/p16INK4a antibody [DCS50.1] ab16123) at 1μg/ml and Detector Antibody Rabbit polyclonal to CDKN2A/p16INK4a (ab7962)
at 0.5μg/ml.
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