Recombinant Human CDKN2AIPNL protein (His tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CDKN2AIPNL also known as CARF or Candidate for ARF involvement in tumor suppressor pathway plays a mechanical role in cell cycle regulation. It interacts with the ARF tumor suppressor pathway and has a mass of around 30 kDa. This target shows expression in several human tissues including the pancreas and hematopoietic cells. CDKN2AIPNL does not have a large number of alternate names keeping its identity largely consistent within research.

Biological function summary

The target modulates the p53 tumor suppressor pathway through its interaction with ARF. CDKN2AIPNL does not function alone but forms a complex with other proteins such as p53 and ARF influencing their cellular roles. Through these interactions it contributes to the regulation of cell growth and apoptosis influencing cancer biology and cellular response to stress.

Pathways

CDKN2AIPNL is heavily involved in the p53 signaling pathway and is also essential for the ARF-p53 interaction. Through these pathways it interfaces with proteins like MDM2 which regulate p53 stability and activity. These connections allow CDKN2AIPNL to influence cell fate decisions and respond to oncogenic signals helping the cell maintain genomic stability.

CDKN2AIPNL is implicated in cancer particularly its deregulation that may lead to tumorigenesis due to its connection with ARF and p53. Abnormal expression or mutations in CDKN2AIPNL also relate to melanoma partly through its association with the p16INK4a protein another significant tumor suppressor. Understanding the dysfunctional interactions in these pathways may contribute towards cancer research and potential therapies.