Recombinant Human CDNF protein is a Human Fragment protein, in the 25 to 187 aa range, expressed in HEK 293, with >=95% purity, <= 0.005 EU/µg endotoxin level and suitable for HPLC, MS.
>=95% HPLC
<= 0.005 EU/µg
HEK 293 cells
Tag free
HPLC, MS
No
LC-MS/MS
Q G Q E A G G R P G A D C E V C K E F L N R F Y K S L I D R G V N F S L D T I E K E L I S F C L D T K G K E N R L C Y Y L G A T K D A A T K I L S E V T R P M S V H M P A M K I C E K L K K L D S Q I C E L K Y E K T L D L A S V D L R K M R V A E L K Q I L H S W G E E C R A C A E K T D Y V N L I Q E L A P K Y A A T H P K T E L
Application | Reactivity | Dilution info | Notes |
---|---|---|---|
Application HPLC | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity).
ARMETL1, ARMETL1, CDNF, Cerebral dopamine neurotrophic factor, ARMET-like protein 1, Conserved dopamine neurotrophic factor
Recombinant Human CDNF protein is a Human Fragment protein, in the 25 to 187 aa range, expressed in HEK 293, with >=95% purity, <= 0.005 EU/µg endotoxin level and suitable for HPLC, MS.
>=95% HPLC
<= 0.005 EU/µg
HEK 293 cells
Tag free
HPLC, MS
No
LC-MS/MS
Yes
Human
Lyophilized contents may appear as either a translucent film or a white powder. This variance does not affect the quality of the product. Store lyophilized form at room temperature. Reconstitute in phosphate buffered saline, aliquot and store at -80°C for 12 months or +4°C for 1 week. Avoid repeated freeze-thaw.
pH: 7.4
Constituents: 10.26% Trehalose, 0.727% Dibasic monohydrogen potassium phosphate, 0.248% Potassium phosphate monobasic
Q G Q E A G G R P G A D C E V C K E F L N R F Y K S L I D R G V N F S L D T I E K E L I S F C L D T K G K E N R L C Y Y L G A T K D A A T K I L S E V T R P M S V H M P A M K I C E K L K K L D S Q I C E L K Y E K T L D L A S V D L R K M R V A E L K Q I L H S W G E E C R A C A E K T D Y V N L I Q E L A P K Y A A T H P K T E L
Fragment
18.57 kDa
18.57 kDa
25 to 187
Recombinant
Lyophilized
Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity).
Belongs to the ARMET family.
Blue Ice
Ambient
Ambient
This supplementary information is collated from multiple sources and compiled automatically.
CDNF also known as Cerebral Dopamine Neurotrophic Factor is a protein that helps in maintaining the proper function of neurons. It has a mass of approximately 18 kDa. This protein is widely expressed in various tissues especially in the brain. CDNF maintains endoplasmic reticulum homeostasis and is involved in the stabilization of dopaminergic neurons. It does this by reducing stress in the endoplasmic reticulum and promoting cell survival mechanisms.
The protein ensures the survival of neurons by modulating cellular stress pathways. CDNF is not known to be part of a larger protein complex. Instead its activity relies on its own structural configuration to influence stress responses and neuron protection. As a secreted protein it directly interacts with and influences cellular mechanisms within the extracellular space contributing to a healthy neuronal environment.
CDNF interacts with at least oxidative stress response pathways and neuroprotection pathways. These pathways underpin its role in counteracting cellular stress related to neurodegeneration. For example CDNF shares a functional connection with proteins like MANF (Mesencephalic Astrocyte-derived Neurotrophic Factor) another neurotrophic factor involved in similar neuroprotective pathways enhancing neuronal survival and recovery from cellular stress.
Neurodegenerative conditions such as Parkinson's disease and Alzheimer's disease are major areas where CDNF shows relevance. In Parkinson's disease CDNF's neuroprotective role helps mitigate the loss of dopaminergic neurons. There is evidence linking CDNF with MANF which also exhibits protective roles in neuronal health. Both proteins aim to promote neuron survival amid progression of neurodegeneration associated with these diseases indicating their potential as therapeutic agents.
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Mass determination by ESI-TOF.
Predicted MW is 18570 Da (+/- 10 Da by ESI-TOF). Observed MW is 18570 Da.
HPLC analysis of ab315437
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